Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1474484..1475046 Replicon chromosome
Accession NZ_CP015267
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A081I0A5
Locus tag MYCOZU2_RS07315 Protein ID WP_036454801.1
Coordinates 1474678..1475046 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A081I0A4
Locus tag MYCOZU2_RS07310 Protein ID WP_036455532.1
Coordinates 1474484..1474681 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS07275 1469588..1470733 - 1146 WP_192579445.1 hypothetical protein -
MYCOZU2_RS07280 1470863..1471936 + 1074 WP_008254380.1 redox-regulated ATPase YchF -
MYCOZU2_RS07285 1471953..1472693 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
MYCOZU2_RS07290 1472781..1473065 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MYCOZU2_RS07295 1473080..1473325 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin -
MYCOZU2_RS07300 1473361..1473912 + 552 WP_089151405.1 VOC family protein -
MYCOZU2_RS07305 1473991..1474389 + 399 WP_036454800.1 VOC family protein -
MYCOZU2_RS07310 1474484..1474681 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYCOZU2_RS07315 1474678..1475046 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCOZU2_RS07320 1475229..1475570 + 342 WP_192579446.1 hypothetical protein -
MYCOZU2_RS31215 1475655..1476014 + 360 WP_192579447.1 hypothetical protein -
MYCOZU2_RS07330 1476199..1476735 + 537 WP_192579448.1 C40 family peptidase -
MYCOZU2_RS07335 1477097..1477420 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
MYCOZU2_RS07340 1477458..1478291 - 834 WP_089151408.1 SAM-dependent methyltransferase -
MYCOZU2_RS07345 1478326..1479009 - 684 WP_089152381.1 guanylate cyclase -
MYCOZU2_RS07350 1479156..1479365 + 210 WP_089151409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13435.74 Da        Isoelectric Point: 6.4862

>T62795 WP_036454801.1 NZ_CP015267:1474678-1475046 [Mycobacterium intracellulare subsp. chimaera]
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA

Download         Length: 369 bp

>T62795 NZ_CP015267:1474678-1475046 [Mycobacterium intracellulare subsp. chimaera]
ATGATCCTCGTCGACACCGCGGTGTGGATCGATCATCTACACACCGCGGAGTTGCGGCTAGTCAAGCTGCTGGAGATCGA
CCAAGTTGGCTGTCATGCGCTGGTCATCGAAGAGCTGGCGCTGGGGTCGATCTCGCGACGTGAGGTGGTGCTCGACCTCC
TCGCGAATCTTCGCCAGTTTCCGACCGTCCAGCACGCCGAGATCCTTCACCTCACCGGTCAACGCAAACTGTATGGACGC
GGTCTCAGTGCGGTCGACGTCCATCTCATGGCCGCCGTCGCCCTGGTTGAAGGCGCGCAGCTGTGGACGAGAGACAAGCG
GTTGAAGGCTGCGTCGGTCGATGCGGGCATCGCACTCTTCGATGCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6871.88 Da        Isoelectric Point: 11.6072

>AT62795 WP_036455532.1 NZ_CP015267:1474484-1474681 [Mycobacterium intracellulare subsp. chimaera]
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG

Download         Length: 198 bp

>AT62795 NZ_CP015267:1474484-1474681 [Mycobacterium intracellulare subsp. chimaera]
ATGCGGACCACAGTCACGATCGACGACGACCTGTTGGCCAAGGCTGCTGAGTTGACCGGCGTGCGCGAGAACGTCGCGTT
GCTCCGCGAGGGATTGCAGACGCTGATCAGGGTGGAAAGCGCTCGCCGACTTGCCGCGCTCGGCGGGACGGATGCCGGGG
CGGTGGCCGCTCCCCGGCGCCGCCGTGGGACTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081I0A5

Antitoxin

Source ID Structure
AlphaFold DB A0A081I0A4

References