62794

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1472781..1473325 Replicon chromosome
Accession NZ_CP015267
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name relE Uniprot ID A0A854HUL3
Locus tag MYCOZU2_RS07295 Protein ID WP_042910934.1
Coordinates 1473080..1473325 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S4Z4W6
Locus tag MYCOZU2_RS07290 Protein ID WP_020821851.1
Coordinates 1472781..1473065 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS07265 1467855..1468454 - 600 WP_009953444.1 lipid droplet-associated protein -
MYCOZU2_RS07270 1468544..1469542 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MYCOZU2_RS07275 1469588..1470733 - 1146 WP_192579445.1 hypothetical protein -
MYCOZU2_RS07280 1470863..1471936 + 1074 WP_008254380.1 redox-regulated ATPase YchF -
MYCOZU2_RS07285 1471953..1472693 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
MYCOZU2_RS07290 1472781..1473065 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCOZU2_RS07295 1473080..1473325 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYCOZU2_RS07300 1473361..1473912 + 552 WP_089151405.1 VOC family protein -
MYCOZU2_RS07305 1473991..1474389 + 399 WP_036454800.1 VOC family protein -
MYCOZU2_RS07310 1474484..1474681 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin -
MYCOZU2_RS07315 1474678..1475046 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin -
MYCOZU2_RS07320 1475229..1475570 + 342 WP_192579446.1 hypothetical protein -
MYCOZU2_RS31215 1475655..1476014 + 360 WP_192579447.1 hypothetical protein -
MYCOZU2_RS07330 1476199..1476735 + 537 WP_192579448.1 C40 family peptidase -
MYCOZU2_RS07335 1477097..1477420 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
MYCOZU2_RS07340 1477458..1478291 - 834 WP_089151408.1 SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(29-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9380.95 Da        Isoelectric Point: 11.2612

>T62794 WP_042910934.1 NZ_CP015267:1473080-1473325 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R

Download         Length: 246 bp

>T62794 NZ_CP015267:1473080-1473325 [Mycobacterium intracellulare subsp. chimaera]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10513.88 Da        Isoelectric Point: 4.3705

>AT62794 WP_020821851.1 NZ_CP015267:1472781-1473065 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Download         Length: 285 bp

>AT62794 NZ_CP015267:1472781-1473065 [Mycobacterium intracellulare subsp. chimaera]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854HUL3

Antitoxin

Source ID Structure
AlphaFold DB S4Z4W6

References