Detailed information of TA system TA062793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1228165..1228818
• Replicon: chromosome
• Accession: NZ_CP015267
• Organism: Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MYCOZU2_RS06145
• Protein ID: WP_008253911.1
• Coordinates: 1228357..1228818 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: X8A187
• Locus tag: MYCOZU2_RS06140
• Protein ID: WP_009957321.1
• Coordinates: 1228165..1228353 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYCOZU2_RS06130	1224138..1225715	+	1578	WP_089152375.1	serine hydrolase	-
MYCOZU2_RS06135	1225712..1228099	+	2388	WP_065507673.1	cation-translocating P-type ATPase	-
MYCOZU2_RS06140	1228165..1228353	+	189	WP_009957321.1	antitoxin	Antitoxin
MYCOZU2_RS06145	1228357..1228818	+	462	WP_008253911.1	SRPBCC family protein	Toxin
MYCOZU2_RS06150	1228905..1229675	+	771	WP_042910815.1	VOC family protein	-
MYCOZU2_RS06155	1229749..1230183	+	435	WP_008253914.1	hypothetical protein	-
MYCOZU2_RS06160	1230188..1230676	-	489	WP_036454690.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
MYCOZU2_RS06165	1230676..1232190	-	1515	WP_089151366.1	carotenoid oxygenase family protein	-
MYCOZU2_RS06170	1232193..1233416	-	1224	WP_089151367.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16639.20 Da
• Isoelectric Point: 8.5617

>T62793 WP_008253911.1 NZ_CP015267:1228357-1228818 [Mycobacterium intracellulare subsp. chimaera]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Nucleotide

• Length: 462 bp

>T62793 NZ_CP015267:1228357-1228818 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACTATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6698.30 Da
• Isoelectric Point: 4.4702

>AT62793 WP_009957321.1 NZ_CP015267:1228165-1228353 [Mycobacterium intracellulare subsp. chimaera]
MGFLDKAKDLLSQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKAAGAADTGDQQN

Nucleotide

• Length: 189 bp

>AT62793 NZ_CP015267:1228165-1228353 [Mycobacterium intracellulare subsp. chimaera]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: X8A187