62792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1005881..1006564 Replicon chromosome
Accession NZ_CP015267
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag MYCOZU2_RS04995 Protein ID WP_007168487.1
Coordinates 1005881..1006288 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag MYCOZU2_RS05000 Protein ID WP_033711258.1
Coordinates 1006292..1006564 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS04970 1001863..1002927 + 1065 WP_042910040.1 IS110 family transposase -
MYCOZU2_RS04975 1003234..1003404 - 171 Protein_972 carnitinyl-CoA dehydratase -
MYCOZU2_RS04985 1005153..1005458 - 306 WP_007168485.1 hypothetical protein -
MYCOZU2_RS04990 1005519..1005860 - 342 WP_007168486.1 hypothetical protein -
MYCOZU2_RS04995 1005881..1006288 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCOZU2_RS05000 1006292..1006564 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MYCOZU2_RS05010 1007060..1008295 - 1236 WP_042909886.1 IS256 family transposase -
MYCOZU2_RS30585 1008937..1009122 + 186 WP_132160383.1 hypothetical protein -
MYCOZU2_RS05015 1009196..1009612 - 417 WP_007168492.1 type II toxin-antitoxin system VapC family toxin -
MYCOZU2_RS05020 1009609..1009860 - 252 WP_007168493.1 ribbon-helix-helix protein, CopG family -
MYCOZU2_RS05030 1010662..1011057 + 396 WP_007168495.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1007060..1008295 1235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T62792 WP_007168487.1 NZ_CP015267:c1006288-1005881 [Mycobacterium intracellulare subsp. chimaera]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T62792 NZ_CP015267:c1006288-1005881 [Mycobacterium intracellulare subsp. chimaera]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT62792 WP_033711258.1 NZ_CP015267:c1006564-1006292 [Mycobacterium intracellulare subsp. chimaera]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT62792 NZ_CP015267:c1006564-1006292 [Mycobacterium intracellulare subsp. chimaera]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References