Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 939606..940273 Replicon chromosome
Accession NZ_CP015267
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag MYCOZU2_RS04655 Protein ID WP_007168407.1
Coordinates 939881..940273 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag MYCOZU2_RS04650 Protein ID WP_007168406.1
Coordinates 939606..939881 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS31480 935110..935436 - 327 WP_033711234.1 hypothetical protein -
MYCOZU2_RS04625 935426..935659 - 234 Protein_900 transposase -
MYCOZU2_RS04630 935677..936888 - 1212 Protein_901 ISL3 family transposase -
MYCOZU2_RS04635 937027..937659 - 633 Protein_902 DDE-type integrase/transposase/recombinase -
MYCOZU2_RS30555 937611..937751 - 141 WP_145958858.1 SDR family oxidoreductase -
MYCOZU2_RS04640 937795..938498 - 704 Protein_904 histidine phosphatase family protein -
MYCOZU2_RS04645 938581..939453 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
MYCOZU2_RS04650 939606..939881 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCOZU2_RS04655 939881..940273 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCOZU2_RS04660 940421..941580 - 1160 Protein_908 trehalose-phosphatase -
MYCOZU2_RS04665 941622..942960 - 1339 Protein_909 DUF1298 domain-containing protein -
MYCOZU2_RS30560 943221..943343 - 123 Protein_910 IS1595 family transposase -
MYCOZU2_RS04675 943679..945013 + 1335 Protein_911 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T62791 WP_007168407.1 NZ_CP015267:939881-940273 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T62791 NZ_CP015267:939881-940273 [Mycobacterium intracellulare subsp. chimaera]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT62791 WP_007168406.1 NZ_CP015267:939606-939881 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT62791 NZ_CP015267:939606-939881 [Mycobacterium intracellulare subsp. chimaera]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References