62790

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 727649..728178 Replicon chromosome
Accession NZ_CP015267
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag MYCOZU2_RS03715 Protein ID WP_007172144.1
Coordinates 727649..727954 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID A0A1X1WNE2
Locus tag MYCOZU2_RS03720 Protein ID WP_042910679.1
Coordinates 727951..728178 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS31135 722727..722867 + 141 WP_007172137.1 hypothetical protein -
MYCOZU2_RS03690 722864..723250 + 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
MYCOZU2_RS03695 723320..723997 + 678 WP_101930854.1 hypothetical protein -
MYCOZU2_RS03700 723997..724329 + 333 WP_033717256.1 hypothetical protein -
MYCOZU2_RS03705 724617..724904 + 288 WP_007172141.1 hypothetical protein -
MYCOZU2_RS30515 726342..727277 + 936 WP_109413176.1 hypothetical protein -
MYCOZU2_RS03715 727649..727954 - 306 WP_007172144.1 hypothetical protein Toxin
MYCOZU2_RS03720 727951..728178 - 228 WP_042910679.1 ribbon-helix-helix protein, CopG family Antitoxin
MYCOZU2_RS03730 728664..730154 + 1491 WP_007172147.1 type VII secretion protein EccB -
MYCOZU2_RS03735 730228..731283 + 1056 WP_007172148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T62790 WP_007172144.1 NZ_CP015267:c727954-727649 [Mycobacterium intracellulare subsp. chimaera]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T62790 NZ_CP015267:c727954-727649 [Mycobacterium intracellulare subsp. chimaera]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8167.24 Da        Isoelectric Point: 5.0079

>AT62790 WP_042910679.1 NZ_CP015267:c728178-727951 [Mycobacterium intracellulare subsp. chimaera]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKIYQANRAAGL

Download         Length: 228 bp

>AT62790 NZ_CP015267:c728178-727951 [Mycobacterium intracellulare subsp. chimaera]
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGATCTATCAGGCGAACCGGGCCGCTGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1WNE2

References