62789

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2420581..2421559 Replicon chromosome
Accession NZ_CP015257
Organism Bacillus wiedmannii strain Bt18679

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6H9J3E5
Locus tag BTI679_RS12495 Protein ID WP_064474160.1
Coordinates 2420581..2421321 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6H9J795
Locus tag BTI679_RS12500 Protein ID WP_064474161.1
Coordinates 2421434..2421559 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTI679_RS12470 (BTI679_25250) 2415781..2416491 + 711 WP_000787500.1 class I SAM-dependent methyltransferase -
BTI679_RS12475 (BTI679_25260) 2416612..2417019 + 408 WP_098112129.1 VOC family protein -
BTI679_RS12480 (BTI679_25270) 2417069..2418754 - 1686 WP_103655336.1 alpha-keto acid decarboxylase family protein -
BTI679_RS12485 (BTI679_25280) 2418862..2419344 + 483 WP_064474158.1 MarR family transcriptional regulator -
BTI679_RS12490 (BTI679_25290) 2419511..2420248 + 738 WP_064474159.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BTI679_RS12495 (BTI679_25300) 2420581..2421321 + 741 WP_064474160.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BTI679_RS12500 2421434..2421559 + 126 WP_064474161.1 hypothetical protein Antitoxin
BTI679_RS12505 (BTI679_25310) 2421635..2421811 + 177 WP_064475198.1 stage II sporulation protein SB -
BTI679_RS12510 (BTI679_25320) 2421855..2422130 - 276 WP_064475199.1 hypothetical protein -
BTI679_RS12515 (BTI679_25330) 2422157..2422951 - 795 WP_176713062.1 hypothetical protein -
BTI679_RS12520 (BTI679_25340) 2423012..2423992 - 981 WP_064475200.1 WXG100 family type VII secretion target -
BTI679_RS12525 (BTI679_25350) 2424325..2424501 + 177 WP_000852619.1 stage II sporulation protein SB -
BTI679_RS12530 (BTI679_25360) 2424643..2426112 + 1470 WP_064475201.1 beta-Ala-His dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28520.37 Da        Isoelectric Point: 8.3034

>T62789 WP_064474160.1 NZ_CP015257:2420581-2421321 [Bacillus wiedmannii]
MVISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIILVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSIIIPLEHIEQLNEQKAVQVENVGIIPAKMVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T62789 NZ_CP015257:2420581-2421321 [Bacillus wiedmannii]
TTGGTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAA
TGAAGAGCTCTACGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAATATTAGTCACCGTGTATT
TCATGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATCGCA
TTTATTTTAACACCAAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAGACTGTTCAATCGATAAAACG
GTCATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACAA
TGGAATGGCATACGGAAGAGGAATATACAAAGAGCTTAAACGCATTTTTAGATTCGTATGGAGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTATTATCATTCCGTT
AGAACACATTGAGCAATTGAATGAACAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATGGTGAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4952.37 Da        Isoelectric Point: 3.9286

>AT62789 WP_064474161.1 NZ_CP015257:2421434-2421559 [Bacillus wiedmannii]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT62789 NZ_CP015257:2421434-2421559 [Bacillus wiedmannii]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGAAAATGAAGATACAACTGATTTCTCGTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H9J3E5

Antitoxin

Source ID Structure
AlphaFold DB A0A6H9J795

References