Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4032729..4033527 Replicon chromosome
Accession NZ_CP015244
Organism Escherichia coli O91 str. RM7190

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I51_RS20930 Protein ID WP_000854902.1
Coordinates 4032729..4033106 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag I51_RS20935 Protein ID WP_001280952.1
Coordinates 4033153..4033527 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I51_RS20900 4028075..4029052 + 978 WP_000633193.1 type II secretion system minor pseudopilin GspK -
I51_RS20905 4029049..4030227 + 1179 WP_000094987.1 type II secretion system protein GspL -
I51_RS20910 4030229..4030765 + 537 WP_000942798.1 GspM family type II secretion system protein YghD -
I51_RS20915 4031108..4031950 - 843 WP_001280537.1 DUF4942 domain-containing protein -
I51_RS20920 4032035..4032232 - 198 WP_000839261.1 DUF957 domain-containing protein -
I51_RS20925 4032244..4032732 - 489 WP_000779175.1 hypothetical protein -
I51_RS20930 4032729..4033106 - 378 WP_000854902.1 TA system toxin CbtA family protein Toxin
I51_RS20935 4033153..4033527 - 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I51_RS20940 4033690..4033911 - 222 WP_000692312.1 DUF987 domain-containing protein -
I51_RS20945 4033974..4034450 - 477 WP_001186725.1 RadC family protein -
I51_RS20950 4034466..4034951 - 486 WP_000849590.1 antirestriction protein -
I51_RS20955 4035006..4035824 - 819 WP_001234626.1 DUF945 domain-containing protein -
I51_RS20965 4035924..4036157 - 234 WP_001119729.1 DUF905 family protein -
I51_RS20970 4036236..4036691 - 456 WP_000581507.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM 3919446..4105966 186520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-118)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14307.29 Da        Isoelectric Point: 7.2922

>T62778 WP_000854902.1 NZ_CP015244:c4033106-4032729 [Escherichia coli O91 str. RM7190]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T62778 NZ_CP015244:c4033106-4032729 [Escherichia coli O91 str. RM7190]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT62778 WP_001280952.1 NZ_CP015244:c4033527-4033153 [Escherichia coli O91 str. RM7190]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT62778 NZ_CP015244:c4033527-4033153 [Escherichia coli O91 str. RM7190]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References