Detailed information of TA system TA062760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 501567..502038
• Replicon: chromosome
• Accession: NZ_CP015243
• Organism: Halotalea alkalilenta strain IHB B 13600

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A172YAZ7
• Locus tag: A5892_RS02255
• Protein ID: WP_064121412.1
• Coordinates: 501567..501833 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: A5892_RS02260
• Protein ID: WP_064124250.1
• Coordinates: 501817..502038 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5892_RS02240	496673..497515	-	843	WP_064121409.1	sugar phosphate isomerase/epimerase	-
A5892_RS02245	497620..498546	-	927	WP_064121410.1	LysR family transcriptional regulator	-
A5892_RS02250	499399..500727	+	1329	WP_064121411.1	IS110 family transposase	-
A5892_RS02255	501567..501833	-	267	WP_064121412.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A5892_RS02260	501817..502038	-	222	WP_064124250.1	TraY domain-containing protein	Antitoxin
A5892_RS02265	502144..503526	-	1383	WP_064121413.1	sigma 54-interacting transcriptional regulator	-
A5892_RS02270	503706..504668	+	963	WP_064121414.1	agmatinase	-
A5892_RS02275	504871..505659	+	789	WP_082890223.1	class II aldolase/adducin family protein	-
A5892_RS02280	505656..506588	+	933	WP_064121415.1	glyoxylate/hydroxypyruvate reductase A	-
A5892_RS02285	506604..506783	-	180	WP_064121416.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10674.47 Da
• Isoelectric Point: 10.8164

>T62760 WP_064121412.1 NZ_CP015243:c501833-501567 [Halotalea alkalilenta]
MKWKVEYASSVQKEIRRLDPQTRQRIRAYMEQRLMTIADPRQLGKPLKGQFSTLWRYRVGDYRIVCNLDDHVLTILVLRV
AHRRQVYD

Nucleotide

• Length: 267 bp

>T62760 NZ_CP015243:c501833-501567 [Halotalea alkalilenta]
ATGAAGTGGAAGGTTGAATACGCCAGCTCGGTCCAGAAGGAGATCCGTCGGCTGGACCCGCAAACCAGACAACGCATCCG
CGCCTATATGGAGCAGCGGCTGATGACCATCGCCGACCCGCGCCAGCTCGGCAAACCGCTGAAGGGCCAGTTCTCCACCC
TATGGCGCTACCGGGTAGGTGACTATCGGATCGTCTGCAATCTCGATGATCACGTCTTGACCATCCTTGTACTCAGAGTG
GCCCACCGTCGGCAGGTATACGACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8598.56 Da
• Isoelectric Point: 4.4594

>AT62760 WP_064124250.1 NZ_CP015243:c502038-501817 [Halotalea alkalilenta]
MATSIRLPIETEQRLNHLAEATGRSKAFYLRKLIEDNLDELEDVYLAERTLERIRQGEEETLSHEAFWHEVEG

Nucleotide

• Length: 222 bp

>AT62760 NZ_CP015243:c502038-501817 [Halotalea alkalilenta]
ATGGCCACTAGCATTCGCCTACCGATCGAGACGGAACAACGCCTGAACCACCTGGCCGAGGCCACCGGACGCTCCAAGGC
CTTCTATCTGCGCAAGCTGATCGAAGACAACCTCGACGAGTTGGAAGATGTCTATCTGGCGGAGCGCACCCTGGAGCGCA
TCCGTCAGGGTGAGGAGGAGACCCTGAGCCACGAAGCGTTCTGGCATGAAGTGGAAGGTTGA

Structures

Toxin

• AlphaFold DB: A0A172YAZ7