Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 36823..37370 Replicon plasmid unnamed1
Accession NZ_CP015242
Organism Escherichia coli strain 2013C-4465

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag A5955_RS27415 Protein ID WP_000969997.1
Coordinates 36823..37104 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U8WKC6
Locus tag A5955_RS27420 Protein ID WP_000079946.1
Coordinates 37101..37370 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5955_RS27395 32824..34170 - 1347 WP_001132032.1 hypothetical protein -
A5955_RS27400 34524..35117 + 594 WP_000517696.1 hypothetical protein -
A5955_RS27405 35399..35986 - 588 WP_001418189.1 serine acetyltransferase -
A5955_RS27410 36286..36627 + 342 WP_000578011.1 hypothetical protein -
A5955_RS27415 36823..37104 - 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A5955_RS27420 37101..37370 - 270 WP_000079946.1 hypothetical protein Antitoxin
A5955_RS31705 37425..37583 - 159 WP_000829588.1 hypothetical protein -
A5955_RS31710 38285..38392 - 108 Protein_48 incFII family plasmid replication initiator RepA -
A5955_RS27430 38415..38663 - 249 WP_000083841.1 replication regulatory protein RepA -
A5955_RS31505 38892..39185 - 294 Protein_50 hypothetical protein -
A5955_RS30715 39484..39699 - 216 Protein_51 IS3 family transposase -
A5955_RS27440 39774..40175 - 402 WP_001222321.1 GspS family T2SS pilot lipoprotein variant EptO -
A5955_RS27445 40269..41102 - 834 WP_000088803.1 A24 family peptidase -
A5955_RS27450 41154..41669 - 516 WP_000998852.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - nleA/espI / exeG / exeE / stcE 1..66029 66029


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.54 Da        Isoelectric Point: 8.4615

>T62759 WP_000969997.1 NZ_CP015242:c37104-36823 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YVLRVLHTAQKWP

Download         Length: 282 bp

>T62759 NZ_CP015242:c37104-36823 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATGTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10210.55 Da        Isoelectric Point: 8.8735

>AT62759 WP_000079946.1 NZ_CP015242:c37370-37101 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT62759 NZ_CP015242:c37370-37101 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGTGGTGATGTGCTTCCACATGACATGGTCGAATCCTCCGCGACTGCATGGCGGGAT
GAAATGAGCAGAAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8WKC6

References