Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4056957..4057662 Replicon chromosome
Accession NZ_CP015241
Organism Escherichia coli strain 2013C-4465

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag A5955_RS19990 Protein ID WP_000539519.1
Coordinates 4057276..4057662 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A5955_RS19985 Protein ID WP_001280945.1
Coordinates 4056957..4057286 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5955_RS19970 4052114..4053025 + 912 WP_001236060.1 glutathione ABC transporter permease GsiD -
A5955_RS19975 4053203..4055551 + 2349 WP_000950334.1 EAL domain-containing protein -
A5955_RS19980 4055559..4056887 + 1329 WP_000086905.1 GGDEF domain-containing protein -
A5955_RS19985 4056957..4057286 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
A5955_RS19990 4057276..4057662 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A5955_RS19995 4057888..4059213 - 1326 WP_000049364.1 30S ribosomal protein S12 methylthiotransferase RimO -
A5955_RS20000 4059426..4059809 + 384 WP_000497137.1 biofilm formation regulator BssR -
A5955_RS20005 4059920..4061035 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
A5955_RS20010 4061032..4061658 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T62747 WP_000539519.1 NZ_CP015241:c4057662-4057276 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T62747 NZ_CP015241:c4057662-4057276 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT62747 WP_001280945.1 NZ_CP015241:c4057286-4056957 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT62747 NZ_CP015241:c4057286-4056957 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References