Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1204328..1205126 | Replicon | chromosome |
| Accession | NZ_CP015240 | ||
| Organism | Escherichia coli strain 2011C-3911 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | A5956_RS06565 | Protein ID | WP_000854902.1 |
| Coordinates | 1204749..1205126 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
| Locus tag | A5956_RS06560 | Protein ID | WP_001280952.1 |
| Coordinates | 1204328..1204702 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A5956_RS06525 | 1201164..1201619 | + | 456 | WP_000581507.1 | hypothetical protein | - |
| A5956_RS06530 | 1201698..1201931 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| A5956_RS06535 | 1202031..1202849 | + | 819 | WP_001234626.1 | DUF945 domain-containing protein | - |
| A5956_RS06540 | 1202904..1203389 | + | 486 | WP_032326869.1 | antirestriction protein | - |
| A5956_RS06545 | 1203405..1203881 | + | 477 | WP_001186726.1 | RadC family protein | - |
| A5956_RS06550 | 1203944..1204165 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| A5956_RS06560 | 1204328..1204702 | + | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| A5956_RS06565 | 1204749..1205126 | + | 378 | WP_000854902.1 | TA system toxin CbtA family protein | Toxin |
| A5956_RS06570 | 1205123..1205611 | + | 489 | WP_000779175.1 | hypothetical protein | - |
| A5956_RS06575 | 1205623..1205820 | + | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| A5956_RS06580 | 1205905..1206747 | + | 843 | WP_001280537.1 | DUF4942 domain-containing protein | - |
| A5956_RS06585 | 1207090..1207626 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| A5956_RS06590 | 1207628..1208806 | - | 1179 | WP_000094974.1 | type II secretion system protein GspL | - |
| A5956_RS06595 | 1208803..1209780 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 1126216..1266425 | 140209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14307.29 Da Isoelectric Point: 7.2922
>T62714 WP_000854902.1 NZ_CP015240:1204749-1205126 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T62714 NZ_CP015240:1204749-1205126 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT62714 WP_001280952.1 NZ_CP015240:1204328-1204702 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT62714 NZ_CP015240:1204328-1204702 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|