Detailed information of TA system TA062701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1513994..1514606
• Replicon: chromosome
• Accession: NZ_CP015238
• Organism: Streptococcus pyogenes strain NS53

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: A4265_RS07590
• Protein ID: WP_063632126.1
• Coordinates: 1514271..1514606 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: A4265_RS07585
• Protein ID: WP_002988079.1
• Coordinates: 1513994..1514281 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4265_RS07560	1509186..1510169	-	984	WP_063632124.1	tagatose-bisphosphate aldolase	-
A4265_RS07565	1510172..1511101	-	930	WP_063632125.1	tagatose-6-phosphate kinase	-
A4265_RS07570	1511147..1511662	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
A4265_RS07575	1511697..1512125	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
A4265_RS07580	1512571..1513344	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
A4265_RS07585	1513994..1514281	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
A4265_RS07590	1514271..1514606	+	336	WP_063632126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A4265_RS07595	1514758..1515228	+	471	WP_063632127.1	integrase	-
A4265_RS07600	1515225..1515725	+	501	WP_076612469.1	site-specific integrase	-
A4265_RS07605	1515857..1516249	-	393	WP_002982716.1	30S ribosomal protein S9	-
A4265_RS07610	1516270..1516716	-	447	WP_002982710.1	50S ribosomal protein L13	-
A4265_RS07615	1516934..1517140	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
A4265_RS07620	1517137..1517835	-	699	WP_063632128.1	hypothetical protein	-
A4265_RS07625	1517971..1518831	-	861	WP_011529009.1	DegV family protein	-
A4265_RS07630	1518928..1519446	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13220.05 Da
• Isoelectric Point: 5.6809

>T62701 WP_063632126.1 NZ_CP015238:1514271-1514606 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEKIISDIEKLEFFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T62701 NZ_CP015238:1514271-1514606 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGAAAATCATTAGCGACATAGAAAAACTCGAGTTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT62701 WP_002988079.1 NZ_CP015238:1513994-1514281 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT62701 NZ_CP015238:1513994-1514281 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94