Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 1869478..1870079 Replicon chromosome
Accession NZ_CP015229
Organism Escherichia coli strain 06-00048

Toxin (Protein)


Gene name doc Uniprot ID A0A193LS81
Locus tag GJ11_RS11170 Protein ID WP_052957703.1
Coordinates 1869699..1870079 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag GJ11_RS11165 Protein ID WP_001190712.1
Coordinates 1869478..1869699 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ11_RS11135 1865648..1866154 + 507 WP_065226838.1 3'-phosphatase -
GJ11_RS11140 1866349..1867077 + 729 WP_065226839.1 hypothetical protein -
GJ11_RS11145 1867144..1867353 + 210 WP_065228224.1 DUF551 domain-containing protein -
GJ11_RS11150 1867346..1867552 + 207 WP_065226840.1 hypothetical protein -
GJ11_RS11155 1867549..1868214 + 666 WP_097463134.1 hypothetical protein -
GJ11_RS11160 1869016..1869405 + 390 WP_046660029.1 DNA repair protein -
GJ11_RS11165 1869478..1869699 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GJ11_RS11170 1869699..1870079 + 381 WP_052957703.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GJ11_RS11175 1870084..1870263 + 180 WP_001697572.1 hypothetical protein -
GJ11_RS11180 1870291..1871334 + 1044 WP_065226841.1 DUF968 domain-containing protein -
GJ11_RS11185 1871423..1871875 + 453 WP_001326849.1 late promoter-activating protein -
GJ11_RS11190 1871961..1873154 + 1194 WP_065226842.1 terminase -
GJ11_RS11195 1873154..1874638 + 1485 WP_000124159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1785272..1963178 177906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13558.31 Da        Isoelectric Point: 5.6343

>T62683 WP_052957703.1 NZ_CP015229:1869699-1870079 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSTVAATLRRLYGSAE

Download         Length: 381 bp

>T62683 NZ_CP015229:1869699-1870079 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCAGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTACTGTCGCCGCCACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT62683 WP_001190712.1 NZ_CP015229:1869478-1869699 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT62683 NZ_CP015229:1869478-1869699 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACTCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CCGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTAAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193LS81

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References