Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1151117..1151596 Replicon chromosome
Accession NZ_CP015229
Organism Escherichia coli strain 06-00048

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A193LPM2
Locus tag GJ11_RS07195 Protein ID WP_065226507.1
Coordinates 1151117..1151404 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A193LPI7
Locus tag GJ11_RS07200 Protein ID WP_042105938.1
Coordinates 1151405..1151596 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ11_RS07165 1148640..1148831 - 192 WP_064236776.1 DUF1482 family protein -
GJ11_RS07170 1148828..1149016 - 189 WP_065226501.1 cell division inhibition protein DicB -
GJ11_RS07175 1149574..1149807 + 234 WP_065226502.1 hypothetical protein -
GJ11_RS07180 1149785..1150192 - 408 WP_065226503.1 hypothetical protein -
GJ11_RS07185 1150208..1150423 - 216 WP_065226504.1 hypothetical protein -
GJ11_RS07190 1150516..1150716 + 201 WP_001092153.1 hypothetical protein -
GJ11_RS07195 1151117..1151404 - 288 WP_065226507.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJ11_RS07200 1151405..1151596 - 192 WP_042105938.1 hypothetical protein Antitoxin
GJ11_RS07205 1151632..1152027 - 396 WP_042105939.1 helix-turn-helix domain-containing protein -
GJ11_RS07210 1152058..1152276 - 219 WP_065228201.1 Cro/Cl family transcriptional regulator -
GJ11_RS07215 1152532..1152819 + 288 WP_042105941.1 helix-turn-helix domain-containing protein -
GJ11_RS07220 1152816..1153241 + 426 WP_065226508.1 Rha family transcriptional regulator -
GJ11_RS07225 1153264..1154232 + 969 WP_071906084.1 helix-turn-helix domain-containing protein -
GJ11_RS07230 1154275..1154676 + 402 WP_040091020.1 DUF977 family protein -
GJ11_RS07235 1154700..1154981 + 282 WP_047088604.1 DNA-binding protein -
GJ11_RS07240 1154978..1155223 + 246 WP_000699804.1 hypothetical protein -
GJ11_RS07245 1155198..1155686 + 489 WP_000004205.1 class I SAM-dependent methyltransferase -
GJ11_RS07250 1155679..1155933 + 255 WP_065226509.1 hypothetical protein -
GJ11_RS07255 1155926..1156237 + 312 WP_065226510.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - msbA / nueA / ompA 1038739..1159035 120296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10941.70 Da        Isoelectric Point: 6.2118

>T62673 WP_065226507.1 NZ_CP015229:c1151404-1151117 [Escherichia coli]
MLPVLWLESADADLDDITSYIARFDIDAAERLWKRLRTCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTISGIE
IVSVVHARRQFPVTP

Download         Length: 288 bp

>T62673 NZ_CP015229:c1151404-1151117 [Escherichia coli]
ATGTTACCGGTTTTATGGCTCGAAAGCGCAGATGCCGACTTGGATGATATAACTAGCTATATTGCTCGTTTTGATATAGA
TGCGGCAGAACGTTTGTGGAAACGCTTAAGGACTTGCGTCCTGCCATTATCTGAGCATCCGTATTTATACCCGCCAAGCG
ACAGAGTTCCGGGTTTGCGTGAAATTGTTGCTCACCCCAATTACATAATTCTATACCGCGTGACAATTTCAGGCATTGAA
ATTGTTAGCGTAGTTCACGCCCGCCGACAGTTCCCTGTAACACCTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7364.29 Da        Isoelectric Point: 5.8256

>AT62673 WP_042105938.1 NZ_CP015229:c1151596-1151405 [Escherichia coli]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVERRMAERFANMRKERSKQ

Download         Length: 192 bp

>AT62673 NZ_CP015229:c1151596-1151405 [Escherichia coli]
ATGAACACAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATCGAGCAAGAAAATAGTTATAACGAATGGCTGCGTGC
AAAAGTGGCCGCAAGCCTTGCTGATCCACGTCCAGCCATCCCACATGACGAAGTTGAACGCAGAATGGCTGAACGCTTTG
CTAACATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193LPM2

Antitoxin

Source ID Structure
AlphaFold DB A0A193LPI7

References