Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1414246..1415041 Replicon chromosome
Accession NZ_CP015228
Organism Escherichia coli strain 09-00049

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag GJ12_RS08425 Protein ID WP_000854914.1
Coordinates 1414667..1415041 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag GJ12_RS08420 Protein ID WP_001280953.1
Coordinates 1414246..1414620 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ12_RS08380 1409601..1410506 + 906 WP_065225569.1 chemotaxis protein -
GJ12_RS08385 1410503..1411573 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
GJ12_RS08395 1411913..1412731 + 819 WP_001234682.1 DUF945 domain-containing protein -
GJ12_RS08400 1412822..1413307 + 486 WP_000214398.1 antirestriction protein -
GJ12_RS08405 1413323..1413799 + 477 WP_001186738.1 RadC family protein -
GJ12_RS08410 1413862..1414083 + 222 WP_000692323.1 DUF987 domain-containing protein -
GJ12_RS08420 1414246..1414620 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GJ12_RS08425 1414667..1415041 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
GJ12_RS08430 1415038..1415529 + 492 WP_000976857.1 hypothetical protein -
GJ12_RS08435 1415541..1415738 + 198 WP_000839282.1 DUF957 domain-containing protein -
GJ12_RS08440 1415823..1416665 + 843 WP_001280481.1 DUF4942 domain-containing protein -
GJ12_RS08450 1417136..1418074 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
GJ12_RS08455 1418129..1418866 + 738 WP_000283664.1 zinc-binding phosphatase -
GJ12_RS08460 1418890..1419444 + 555 WP_001001902.1 molecular chaperone YcdY -
GJ12_RS08465 1419546..1420037 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - iroB / csgG / csgF / csgE / csgD / csgB / csgA / csgC 1384832..1425602 40770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T62651 WP_000854914.1 NZ_CP015228:1414667-1415041 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T62651 NZ_CP015228:1414667-1415041 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT62651 WP_001280953.1 NZ_CP015228:1414246-1414620 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT62651 NZ_CP015228:1414246-1414620 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References