Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2542621..2543321 Replicon chromosome
Accession NZ_CP015227
Organism Enterobacter sp. ODB01

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag A4308_RS12115 Protein ID WP_063308540.1
Coordinates 2542621..2542998 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag A4308_RS12120 Protein ID WP_063308541.1
Coordinates 2543100..2543321 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4308_RS12090 2538090..2539208 - 1119 WP_045281291.1 cytochrome c552 -
A4308_RS12095 2539337..2540473 - 1137 WP_049010820.1 DltD -
A4308_RS12105 2540973..2541818 - 846 WP_063308538.1 DUF4942 domain-containing protein -
A4308_RS21860 2541900..2542103 - 204 WP_071890832.1 DUF957 domain-containing protein -
A4308_RS12110 2542136..2542624 - 489 WP_063308539.1 hypothetical protein -
A4308_RS12115 2542621..2542998 - 378 WP_063308540.1 TA system toxin CbtA family protein Toxin
A4308_RS12120 2543100..2543321 - 222 WP_063308541.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A4308_RS12125 2543345..2543566 - 222 WP_063308542.1 DUF987 domain-containing protein -
A4308_RS12130 2543578..2544057 - 480 WP_063308543.1 DNA repair protein RadC -
A4308_RS12135 2544069..2544539 - 471 WP_063308544.1 antirestriction protein -
A4308_RS12140 2544651..2544848 - 198 WP_063308545.1 DUF905 family protein -
A4308_RS12145 2544971..2545435 - 465 WP_063308546.1 hypothetical protein -
A4308_RS12150 2545500..2545904 - 405 WP_063308547.1 hypothetical protein -
A4308_RS12155 2546117..2547004 - 888 WP_063308771.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(10-73)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14417.24 Da        Isoelectric Point: 7.7731

>T62638 WP_063308540.1 NZ_CP015227:c2542998-2542621 [Enterobacter sp. ODB01]
MQTYSLSSTQEASPRPSSVEICQRLLIHRLYRHYELSLNDTPFCNDSVIQEHIDASISLCDTVNFIVEKYDQVRTDRRGF
NAEIQSPPLTSIDIFRARKTNGLMTRNNSKVMNDITTGKYREVKS

Download         Length: 378 bp

>T62638 NZ_CP015227:c2542998-2542621 [Enterobacter sp. ODB01]
ATGCAAACCTATTCATTATCCTCCACGCAGGAGGCTTCACCACGCCCATCATCCGTGGAGATCTGTCAGCGGCTTCTGAT
CCACCGGCTGTACCGTCACTACGAGCTGTCGCTAAACGATACGCCATTCTGCAACGACAGCGTGATTCAGGAGCATATAG
ACGCCAGCATCTCGCTGTGCGACACCGTGAATTTTATCGTGGAGAAATACGACCAGGTTCGTACAGACCGTCGCGGTTTT
AACGCAGAAATTCAGTCGCCGCCTCTCACTAGTATCGACATTTTTCGCGCCCGTAAAACCAACGGGTTGATGACCCGCAA
CAATTCCAAAGTGATGAACGATATCACCACAGGTAAATACCGTGAGGTGAAGTCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7964.07 Da        Isoelectric Point: 6.7559

>AT62638 WP_063308541.1 NZ_CP015227:c2543321-2543100 [Enterobacter sp. ODB01]
MSNKIPAVNHGIADRASITGQFIDADLHHLDHAFSLLLKHLELMLVSGELNPRYRHGVTLDAKGLTYDTGSLG

Download         Length: 222 bp

>AT62638 NZ_CP015227:c2543321-2543100 [Enterobacter sp. ODB01]
TTGTCGAATAAAATACCGGCAGTAAATCACGGTATCGCTGACAGAGCCAGCATAACCGGTCAGTTCATCGACGCGGATTT
GCACCATCTCGATCATGCGTTTTCACTGCTGTTGAAACACCTGGAACTGATGCTGGTATCCGGTGAGCTTAATCCCCGCT
ATCGGCACGGTGTCACGCTTGATGCAAAAGGGTTGACTTACGACACCGGTTCCCTCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References