Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1906611..1907231 Replicon chromosome
Accession NZ_CP015227
Organism Enterobacter sp. ODB01

Toxin (Protein)


Gene name Hha Uniprot ID A0A2W0G488
Locus tag A4308_RS09115 Protein ID WP_014882802.1
Coordinates 1906611..1906829 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag A4308_RS09120 Protein ID WP_008499288.1
Coordinates 1906857..1907231 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4308_RS09085 1902620..1902880 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
A4308_RS09090 1902883..1903023 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
A4308_RS09095 1903020..1903730 - 711 WP_063308496.1 GNAT family N-acetyltransferase -
A4308_RS09100 1903832..1905292 + 1461 WP_014882799.1 PLP-dependent aminotransferase family protein -
A4308_RS09105 1905264..1905731 - 468 WP_014882800.1 membrane protein -
A4308_RS09110 1905850..1906401 - 552 WP_063308497.1 maltose O-acetyltransferase -
A4308_RS09115 1906611..1906829 - 219 WP_014882802.1 hemolysin expression modulator Hha Toxin
A4308_RS09120 1906857..1907231 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
A4308_RS09125 1907743..1910889 - 3147 WP_014882803.1 multidrug efflux RND transporter permease subunit -
A4308_RS09130 1910912..1912105 - 1194 WP_014882804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T62636 WP_014882802.1 NZ_CP015227:c1906829-1906611 [Enterobacter sp. ODB01]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T62636 NZ_CP015227:c1906829-1906611 [Enterobacter sp. ODB01]
ATGTCTGAAAAACCACTCACAAAGGTCGATTATTTGATGCGCTTACGCCGTTGTCAGTCAATTGACACCCTCGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCTGACCATCGCCTCGCTGAGC
TAACGATGAATAAGTTATATGACAAAATTCCCACATCCGTGTGGAAATTTGTACGTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT62636 WP_008499288.1 NZ_CP015227:c1907231-1906857 [Enterobacter sp. ODB01]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT62636 NZ_CP015227:c1907231-1906857 [Enterobacter sp. ODB01]
ATGGACGAGTACTCGCCAAAACGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGATCCAACGTCTGCCATCAATTTACAGTTGAACGAGCTTATCGAGC
ATATCGCTACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCGCAAGATTTGCAAAAATGGCGCAAATCGGGAAACCGACT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCCGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G488

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References