Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 620183..620840 Replicon chromosome
Accession NZ_CP015227
Organism Enterobacter sp. ODB01

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag A4308_RS02950 Protein ID WP_014885136.1
Coordinates 620183..620593 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag A4308_RS02955 Protein ID WP_010435322.1
Coordinates 620574..620840 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4308_RS02930 616177..617910 - 1734 WP_032635612.1 single-stranded-DNA-specific exonuclease RecJ -
A4308_RS02935 617916..618629 - 714 WP_045134112.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A4308_RS02940 618658..619554 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
A4308_RS02945 619656..620177 + 522 WP_014885135.1 flavodoxin FldB -
A4308_RS02950 620183..620593 - 411 WP_014885136.1 protein YgfX Toxin
A4308_RS02955 620574..620840 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
A4308_RS02960 621135..622115 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
A4308_RS02965 622200..622859 - 660 WP_023331242.1 hemolysin III family protein -
A4308_RS02970 623125..623856 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
A4308_RS02975 623973..625406 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T62633 WP_014885136.1 NZ_CP015227:c620593-620183 [Enterobacter sp. ODB01]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T62633 NZ_CP015227:c620593-620183 [Enterobacter sp. ODB01]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTATTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT62633 WP_010435322.1 NZ_CP015227:c620840-620574 [Enterobacter sp. ODB01]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT62633 NZ_CP015227:c620840-620574 [Enterobacter sp. ODB01]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References