Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 14028..14731 Replicon chromosome
Accession NZ_CP015227
Organism Enterobacter sp. ODB01

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag A4308_RS00080 Protein ID WP_063308406.1
Coordinates 14028..14369 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag A4308_RS00085 Protein ID WP_063308407.1
Coordinates 14390..14731 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4308_RS00060 10054..11061 + 1008 WP_045134373.1 LacI family DNA-binding transcriptional regulator -
A4308_RS00065 11047..11472 - 426 WP_045134374.1 FosA/FosA2 family fosfomycin resistance glutathione transferase -
A4308_RS00070 11672..12616 + 945 WP_063308405.1 tryptophan--tRNA ligase -
A4308_RS00075 12762..13769 - 1008 WP_017880110.1 restriction endonuclease -
A4308_RS00080 14028..14369 - 342 WP_063308406.1 TA system toxin CbtA family protein Toxin
A4308_RS00085 14390..14731 - 342 WP_063308407.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A4308_RS00090 14742..15284 - 543 WP_063308408.1 DNA repair protein RadC -
A4308_RS00095 15297..15740 - 444 WP_063308409.1 antirestriction protein -
A4308_RS00100 15771..16592 - 822 WP_063308410.1 DUF945 domain-containing protein -
A4308_RS00105 16712..17185 - 474 WP_063308411.1 hypothetical protein -
A4308_RS00110 17257..17709 - 453 WP_082826293.1 hypothetical protein -
A4308_RS00115 17745..18461 - 717 WP_063308413.1 WYL domain-containing protein -
A4308_RS00120 18705..19580 - 876 WP_063308414.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12777.76 Da        Isoelectric Point: 8.9919

>T62632 WP_063308406.1 NZ_CP015227:c14369-14028 [Enterobacter sp. ODB01]
MKTLPATTPQAAKLCLSPVTVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWEEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T62632 NZ_CP015227:c14369-14028 [Enterobacter sp. ODB01]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGAAGCTATGTCTGTCGCCCGTAACTGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAGCATTATGGCCTGACACTCAACGACACGCCGTTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCTGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGAGGATTC
AACTGGGAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12722.34 Da        Isoelectric Point: 6.4739

>AT62632 WP_063308407.1 NZ_CP015227:c14731-14390 [Enterobacter sp. ODB01]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp

>AT62632 NZ_CP015227:c14731-14390 [Enterobacter sp. ODB01]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCCGACCGGGCCAGTATCACCGGAAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References