62622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 500208..501157 Replicon plasmid pR8L1
Accession NZ_CP015203
Organism Rhodococcus sp. 008

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag AOT96_RS32760 Protein ID WP_058228595.1
Coordinates 500582..501157 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag AOT96_RS32755 Protein ID WP_058228594.1
Coordinates 500208..500585 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT96_RS32720 495254..495511 - 258 WP_063892191.1 hypothetical protein -
AOT96_RS32725 495508..495879 - 372 WP_058228603.1 MerR family transcriptional regulator -
AOT96_RS32730 496058..496516 + 459 WP_058228604.1 Hsp20 family protein -
AOT96_RS32735 496622..496882 + 261 WP_058228605.1 hypothetical protein -
AOT96_RS32740 497345..498241 - 897 WP_065353005.1 SDR family oxidoreductase -
AOT96_RS35580 498474..498557 + 84 Protein_481 hypothetical protein -
AOT96_RS32745 499010..499168 + 159 WP_156779019.1 hypothetical protein -
AOT96_RS35070 499296..499632 + 337 Protein_483 WhiB family transcriptional regulator -
AOT96_RS32750 499754..499972 + 219 WP_058228593.1 hypothetical protein -
AOT96_RS32755 500208..500585 + 378 WP_058228594.1 hypothetical protein Antitoxin
AOT96_RS32760 500582..501157 + 576 WP_058228595.1 zeta toxin family protein Toxin
AOT96_RS32765 501203..501439 - 237 WP_141695893.1 hypothetical protein -
AOT96_RS32770 501587..502088 + 502 Protein_488 Fic family protein -
AOT96_RS32775 502174..503454 - 1281 WP_064073797.1 IS256 family transposase -
AOT96_RS32780 503822..504055 - 234 WP_058228420.1 hypothetical protein -
AOT96_RS32785 504357..504992 - 636 WP_058228419.1 hypothetical protein -
AOT96_RS32790 505277..505674 - 398 Protein_492 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..694228 694228
- flank IS/Tn - - 502174..503454 1280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-60)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20958.86 Da        Isoelectric Point: 5.6488

>T62622 WP_058228595.1 NZ_CP015203:500582-501157 [Rhodococcus sp. 008]
VRRLDLVVGPNGAGKSTFVEQSLAPLLSGSVFVNADVIAKDRWPDAAEEHSYEAARIAATMRGALIERGESFIAETVFSH
PSKLELIDRARQAGFVVVLHVVLVPVELSVARVAGRVVEGGHSVPEGKIRERYERLWPLVVDAIDRSDHATVYDNTAPDV
TRIVARFVDGDPVGEITWPAWTPVEFLRAQK

Download         Length: 576 bp

>T62622 NZ_CP015203:500582-501157 [Rhodococcus sp. 008]
GTGAGACGTCTCGATCTTGTCGTCGGACCGAACGGGGCCGGCAAATCGACGTTCGTCGAGCAGAGTCTAGCGCCCCTGCT
TTCCGGCAGCGTCTTCGTCAACGCGGATGTGATCGCCAAGGACCGCTGGCCTGATGCTGCCGAGGAACATTCCTATGAGG
CCGCGCGGATTGCGGCGACTATGCGCGGTGCCCTGATTGAGCGGGGTGAGTCGTTCATCGCCGAGACGGTATTTTCGCAT
CCGTCGAAATTGGAGTTGATCGACCGTGCGCGCCAGGCCGGTTTCGTTGTCGTGCTGCACGTGGTACTGGTTCCGGTCGA
GTTATCGGTCGCTCGTGTTGCCGGGCGGGTTGTCGAGGGTGGGCATTCGGTTCCTGAGGGGAAGATTCGAGAGCGATATG
AGCGGTTATGGCCGCTGGTCGTCGACGCGATTGATCGGTCAGACCACGCGACCGTATACGACAACACTGCCCCGGATGTC
ACGCGCATCGTTGCTCGGTTCGTAGATGGCGATCCGGTCGGCGAGATTACCTGGCCAGCATGGACTCCGGTCGAGTTCCT
GAGAGCGCAGAAGTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13585.12 Da        Isoelectric Point: 6.0954

>AT62622 WP_058228594.1 NZ_CP015203:500208-500585 [Rhodococcus sp. 008]
MTEVVDKVTRFSSELVDAAAAEGQREHRSARQQLEHWARVGREVSNQRQVARQRVEAALAGRIPLSVLSAEEGAVFNAEI
AATLEESIATGNHAAERAVQGRATISLDEHGRVVKYLPDGSQTVL

Download         Length: 378 bp

>AT62622 NZ_CP015203:500208-500585 [Rhodococcus sp. 008]
ATGACGGAAGTCGTCGACAAGGTCACCAGATTCTCATCAGAGCTCGTCGATGCCGCGGCCGCGGAGGGACAGCGCGAGCA
TCGCTCAGCACGCCAGCAGCTCGAGCACTGGGCCCGTGTCGGTCGTGAGGTGTCGAACCAGCGCCAAGTTGCACGCCAGC
GTGTCGAGGCCGCCCTCGCCGGCCGTATCCCACTAAGCGTGCTCTCCGCTGAAGAAGGCGCGGTATTCAACGCCGAGATT
GCGGCCACCCTCGAAGAATCGATCGCGACAGGTAACCATGCCGCCGAACGCGCAGTTCAGGGGCGCGCAACGATTTCGCT
CGACGAGCACGGCCGGGTTGTCAAGTATCTGCCTGACGGTTCGCAGACCGTCTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References