Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 127207..127743 Replicon plasmid pR8L1
Accession NZ_CP015203
Organism Rhodococcus sp. 008

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AOT96_RS30900 Protein ID WP_042926284.1
Coordinates 127207..127521 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AOT96_RS30905 Protein ID WP_042926289.1
Coordinates 127522..127743 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT96_RS34980 123123..123714 + 592 Protein_125 IS6 family transposase -
AOT96_RS30885 123752..124303 + 552 Protein_126 DUF1016 domain-containing protein -
AOT96_RS30890 124432..125229 - 798 WP_058228359.1 hypothetical protein -
AOT96_RS30895 125229..127184 - 1956 WP_058228366.1 hypothetical protein -
AOT96_RS30900 127207..127521 - 315 WP_042926284.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AOT96_RS30905 127522..127743 - 222 WP_042926289.1 hypothetical protein Antitoxin
AOT96_RS35875 127927..128274 - 348 WP_063892177.1 hypothetical protein -
AOT96_RS30915 128304..129605 - 1302 WP_058228360.1 AAA family ATPase -
AOT96_RS30920 129676..130863 - 1188 WP_058228361.1 hypothetical protein -
AOT96_RS30925 130860..131054 - 195 WP_037129470.1 hypothetical protein -
AOT96_RS30930 131051..132289 - 1239 WP_058228362.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..694228 694228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(12-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11063.65 Da        Isoelectric Point: 4.8000

>T62619 WP_042926284.1 NZ_CP015203:c127521-127207 [Rhodococcus sp. 008]
VRPIHDAHLETLCPVLVLTRELVRPHLGTVTVAPVRAEGRGLSTELSLGEDNGVEDGSVVDCDGVTTIPVSALGVNRGFL
LPAQEVLLTRALRSAFDLESLGRQ

Download         Length: 315 bp

>T62619 NZ_CP015203:c127521-127207 [Rhodococcus sp. 008]
GTGCGGCCAATCCATGACGCCCACCTCGAAACGCTCTGTCCGGTCTTGGTTCTGACGAGGGAGCTGGTTCGGCCTCATCT
GGGGACGGTCACTGTTGCTCCCGTTCGTGCGGAGGGGCGGGGGTTATCGACCGAGCTGAGTTTGGGCGAAGACAACGGTG
TCGAGGACGGATCGGTTGTCGACTGCGACGGGGTGACGACCATCCCGGTGTCGGCACTCGGGGTGAATCGAGGATTTCTC
TTGCCTGCTCAGGAAGTGTTGTTGACCAGGGCATTGCGATCAGCATTTGATCTCGAGTCATTAGGACGCCAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7870.93 Da        Isoelectric Point: 8.9167

>AT62619 WP_042926289.1 NZ_CP015203:c127743-127522 [Rhodococcus sp. 008]
MSTQIAVRLPEDIVVFLDSEVSGGRAKSRAQVVLRALEREQRRQLAARDVEILSDGLGTGSDVNIAAAHGKKN

Download         Length: 222 bp

>AT62619 NZ_CP015203:c127743-127522 [Rhodococcus sp. 008]
ATGAGCACGCAGATCGCGGTACGGCTACCCGAGGACATCGTGGTGTTTCTCGACAGTGAGGTCAGTGGTGGGCGCGCGAA
AAGCCGTGCTCAAGTTGTGCTTCGAGCGTTGGAGCGTGAGCAGCGTCGACAGCTTGCAGCCCGAGACGTGGAGATCTTGT
CTGATGGTCTCGGAACCGGTAGCGATGTGAATATCGCCGCCGCGCACGGGAAGAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References