Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 439697..440300 Replicon chromosome
Accession NZ_CP015196
Organism Streptococcus marmotae strain HTS5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A4H00_RS02230 Protein ID WP_067086783.1
Coordinates 440109..440300 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A4H00_RS02225 Protein ID WP_067086781.1
Coordinates 439697..440074 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4H00_RS02210 435314..436306 + 993 WP_067086772.1 tRNA dihydrouridine synthase DusB -
A4H00_RS02215 436508..438958 - 2451 WP_067086775.1 ATP-dependent Clp protease ATP-binding subunit -
A4H00_RS02220 438960..439418 - 459 WP_067086778.1 CtsR family transcriptional regulator -
A4H00_RS02225 439697..440074 - 378 WP_067086781.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4H00_RS02230 440109..440300 - 192 WP_067086783.1 type II toxin-antitoxin system HicA family toxin Toxin
A4H00_RS02235 440485..440898 - 414 WP_067086786.1 hypothetical protein -
A4H00_RS02240 440891..441202 - 312 WP_067086789.1 hypothetical protein -
A4H00_RS02245 441337..441690 - 354 WP_067086791.1 replication protein -
A4H00_RS02250 441745..442365 - 621 WP_067086793.1 hypothetical protein -
A4H00_RS02255 442406..442762 - 357 WP_067086796.1 minor capsid protein -
A4H00_RS02260 442849..443016 - 168 WP_082815654.1 DUF2292 domain-containing protein -
A4H00_RS02265 443025..443276 - 252 WP_067086800.1 hypothetical protein -
A4H00_RS02270 443273..443524 - 252 WP_067086803.1 hypothetical protein -
A4H00_RS02275 443831..444904 - 1074 WP_099092180.1 virulence-associated E family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 335672..540630 204958


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6975.25 Da        Isoelectric Point: 10.3755

>T62610 WP_067086783.1 NZ_CP015196:c440300-440109 [Streptococcus marmotae]
MPLTGKEMVKLAEANGWKEIRTNGSHHHFKKEGCSKIVTIPVHGNKDLGKGLEKKILKDLGLL

Download         Length: 192 bp

>T62610 NZ_CP015196:c440300-440109 [Streptococcus marmotae]
ATGCCACTTACAGGCAAAGAAATGGTAAAACTTGCAGAGGCCAACGGGTGGAAAGAAATCCGAACTAATGGAAGTCATCA
CCATTTCAAAAAAGAAGGATGTTCGAAAATAGTTACAATTCCAGTCCATGGAAATAAGGACTTAGGGAAAGGACTAGAGA
AGAAAATCCTGAAAGATTTGGGGCTATTATAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14187.04 Da        Isoelectric Point: 4.3514

>AT62610 WP_067086781.1 NZ_CP015196:c440074-439697 [Streptococcus marmotae]
MLKSYPAIFHKEDTGYWVEFPEFGGGTRGDNLEEAMYNAREFLESSIALYIDEGLELPKVSNIEDLSAPDGFVTMIQADP
TPFIKNNKAIRKNVTVPEWLTRLADREGLNYSEVLTKALETRLQV

Download         Length: 378 bp

>AT62610 NZ_CP015196:c440074-439697 [Streptococcus marmotae]
ATGTTGAAATCTTATCCAGCTATTTTTCATAAAGAAGATACAGGCTACTGGGTGGAGTTTCCAGAATTTGGCGGAGGTAC
TAGGGGTGACAACCTAGAAGAAGCTATGTATAACGCCCGCGAGTTTTTAGAAAGTTCTATCGCTCTTTATATTGATGAGG
GGTTGGAATTGCCAAAAGTGAGCAATATAGAAGACTTGAGCGCCCCCGATGGCTTTGTCACAATGATACAAGCTGATCCA
ACACCTTTCATTAAGAATAATAAAGCGATTCGAAAGAATGTCACGGTGCCCGAATGGTTGACTAGACTCGCTGACCGTGA
GGGGTTGAACTATTCTGAGGTACTAACAAAAGCATTAGAAACACGTTTGCAAGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References