Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/PIN(toxin) |
| Location | 1104064..1104917 | Replicon | chromosome |
| Accession | NC_011593 | ||
| Organism | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | BLON_RS04730 | Protein ID | WP_014484735.1 |
| Coordinates | 1104426..1104917 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B7GQF3 |
| Locus tag | BLON_RS04725 | Protein ID | WP_012577299.1 |
| Coordinates | 1104064..1104426 (+) | Length | 121 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BLON_RS04720 (Blon_0932) | 1101219..1103918 | + | 2700 | WP_012577298.1 | aconitate hydratase AcnA | - |
| BLON_RS04725 (Blon_0933) | 1104064..1104426 | + | 363 | WP_012577299.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| BLON_RS04730 (Blon_0934) | 1104426..1104917 | + | 492 | WP_014484735.1 | PIN domain-containing protein | Toxin |
| BLON_RS04735 (Blon_0935) | 1104977..1107082 | - | 2106 | WP_012577301.1 | DUF262 domain-containing protein | - |
| BLON_RS04740 (Blon_0936) | 1107171..1107812 | - | 642 | WP_013140893.1 | GNAT family N-acetyltransferase | - |
| BLON_RS13495 (Blon_0937) | 1107853..1107993 | - | 141 | Protein_941 | DNA-binding response regulator | - |
| BLON_RS14195 | 1107947..1108165 | + | 219 | WP_014484736.1 | hypothetical protein | - |
| BLON_RS04750 (Blon_0938) | 1108162..1109064 | + | 903 | WP_014484737.1 | Bax inhibitor-1/YccA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 18398.02 Da Isoelectric Point: 4.5590
>T6261 WP_014484735.1 NC_011593:1104426-1104917 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLLSSAIRREFKPNESEVENFTRNF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLLSSAIRREFKPNESEVENFTRNF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE
Download Length: 492 bp
>T6261 NC_011593:1104426-1104917 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATTATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCAACTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATTATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCAACTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA
Antitoxin
Download Length: 121 a.a. Molecular weight: 14034.08 Da Isoelectric Point: 5.0733
>AT6261 WP_012577299.1 NC_011593:1104064-1104426 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGTGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGTGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD
Download Length: 363 bp
>AT6261 NC_011593:1104064-1104426 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGCACCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGCACCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Olga Averina et al. (2015) Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697. Anaerobe 35(Pt B):59-67. [PubMed:26210151]