Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 89258..89882 Replicon chromosome
Accession NZ_CP015196
Organism Streptococcus marmotae strain HTS5

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag A4H00_RS00385 Protein ID WP_067085942.1
Coordinates 89258..89605 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag A4H00_RS00390 Protein ID WP_067085945.1
Coordinates 89595..89882 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4H00_RS00365 85063..86514 + 1452 WP_067085929.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase -
A4H00_RS00370 87077..87796 - 720 WP_067085933.1 rRNA pseudouridine synthase -
A4H00_RS00375 87923..88627 - 705 WP_067085936.1 glucosamine-6-phosphate deaminase -
A4H00_RS00385 89258..89605 - 348 WP_067085942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4H00_RS00390 89595..89882 - 288 WP_067085945.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A4H00_RS00395 89982..90431 - 450 WP_067085947.1 type II toxin-antitoxin system HicB family antitoxin -
A4H00_RS00400 90469..90648 - 180 WP_067085951.1 type II toxin-antitoxin system HicA family toxin -
A4H00_RS00405 90834..91247 - 414 WP_067085954.1 hypothetical protein -
A4H00_RS00410 91228..91650 - 423 WP_067085956.1 hypothetical protein -
A4H00_RS00415 91696..91974 - 279 WP_067085959.1 hypothetical protein -
A4H00_RS00420 91964..92302 - 339 WP_067085961.1 replication protein -
A4H00_RS00425 92335..92913 - 579 WP_157770960.1 hypothetical protein -
A4H00_RS00430 93163..94419 - 1257 WP_067085967.1 ISL3 family transposase -
A4H00_RS00435 94602..94853 - 252 WP_067085970.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 93163..94419 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(11-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13324.17 Da        Isoelectric Point: 5.7348

>T62608 WP_067085942.1 NZ_CP015196:c89605-89258 [Streptococcus marmotae]
MVSDNKSYSLLISEKVQEQLRAIKSYIETTYFSDQAGANTVNNILYGLERLELFPEAGFNADERVGEAIYPPYNTRCIVL
GDYLAFYHILEDKKTVFVSDIIHSKQDYIRLFKKK

Download         Length: 348 bp

>T62608 NZ_CP015196:c89605-89258 [Streptococcus marmotae]
TTGGTATCTGATAACAAATCTTATAGCCTTCTTATTTCTGAAAAAGTGCAGGAACAGTTACGGGCGATAAAAAGCTATAT
TGAAACTACATACTTTTCAGATCAGGCAGGAGCTAACACTGTAAACAATATTCTTTACGGGCTAGAACGGCTTGAACTTT
TTCCAGAAGCAGGTTTTAACGCAGATGAGAGAGTAGGGGAAGCTATTTACCCGCCCTACAATACCCGTTGCATTGTTTTA
GGGGACTACCTAGCCTTTTATCACATTTTGGAAGATAAGAAAACCGTCTTCGTATCTGATATTATCCATAGCAAACAAGA
TTACATTAGACTGTTCAAGAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10598.04 Da        Isoelectric Point: 4.8228

>AT62608 WP_067085945.1 NZ_CP015196:c89882-89595 [Streptococcus marmotae]
MHVLEKNTQVNFKTNSDLLEKAKAIITAQNLDMTATFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFADLEA
GRVYSTNEVRANLGI

Download         Length: 288 bp

>AT62608 NZ_CP015196:c89882-89595 [Streptococcus marmotae]
ATGCATGTTTTAGAGAAAAATACACAAGTCAATTTTAAGACGAATAGTGATTTACTAGAGAAAGCCAAAGCTATTATCAC
AGCCCAAAATCTTGATATGACAGCTACTTTTAATTTATTTTTAGAAAATATTGTACAAAATAAAGCCTTACCTTTTGAAA
CTGATACCGATAAAGAACGGGCGGAACTACTTGCAGGCTTACGGGCTGAAATTGCCAAAAGTTTTGCAGATTTAGAAGCT
GGAAGAGTGTACAGTACTAACGAAGTGAGGGCTAACCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References