Detailed information of TA system TA062606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 3193113..3193684
• Replicon: chromosome
• Accession: NZ_CP015194
• Organism: Shewanella sp. Pdp11

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AYJ58_RS14160
• Protein ID: WP_106650611.1
• Coordinates: 3193113..3193424 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q07XG1
• Locus tag: AYJ58_RS14165
• Protein ID: WP_011638898.1
• Coordinates: 3193424..3193684 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYJ58_RS14145	3188667..3189485	-	819	WP_106650609.1	tRNA (adenine(22)-N(1))-methyltransferase TrmK	-
AYJ58_RS14155	3190009..3193089	-	3081	WP_106650610.1	Tn3 family transposase	-
AYJ58_RS14160	3193113..3193424	-	312	WP_106650611.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AYJ58_RS14165	3193424..3193684	-	261	WP_011638898.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AYJ58_RS14170	3193854..3194474	+	621	WP_106650612.1	recombinase family protein	-
AYJ58_RS14175	3194546..3195376	-	831	WP_106650613.1	patatin family protein	-
AYJ58_RS14180	3195379..3196035	-	657	WP_106650614.1	hypothetical protein	-
AYJ58_RS14185	3196542..3196874	-	333	WP_011787803.1	TraR/DksA C4-type zinc finger protein	-
AYJ58_RS14190	3196965..3197819	-	855	WP_106650615.1	universal stress protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11848.67 Da
• Isoelectric Point: 8.5341

>T62606 WP_106650611.1 NZ_CP015194:c3193424-3193113 [Shewanella sp. Pdp11]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPSLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Nucleotide

• Length: 312 bp

>T62606 NZ_CP015194:c3193424-3193113 [Shewanella sp. Pdp11]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCAGCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9330.74 Da
• Isoelectric Point: 6.4546

>AT62606 WP_011638898.1 NZ_CP015194:c3193684-3193424 [Shewanella sp. Pdp11]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Nucleotide

• Length: 261 bp

>AT62606 NZ_CP015194:c3193684-3193424 [Shewanella sp. Pdp11]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTGATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8ZVH1