Detailed information of TA system TA062604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1994563..1996279
• Replicon: chromosome
• Accession: NZ_CP015194
• Organism: Shewanella sp. Pdp11

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: AYJ58_RS08790
• Protein ID: WP_106649806.1
• Coordinates: 1995344..1996279 (+)
• Length: 312 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: AYJ58_RS08785
• Protein ID: WP_106649805.1
• Coordinates: 1994563..1995351 (+)
• Length: 263 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYJ58_RS08765	1990069..1991277	+	1209	WP_001206290.1	IS4-like element IS10A family transposase	-
AYJ58_RS08770	1991419..1992528	+	1110	WP_157825771.1	hypothetical protein	-
AYJ58_RS08775	1992667..1993590	+	924	WP_157825772.1	hypothetical protein	-
AYJ58_RS08780	1993898..1994308	-	411	WP_106649804.1	hypothetical protein	-
AYJ58_RS08785	1994563..1995351	+	789	WP_106649805.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
AYJ58_RS08790	1995344..1996279	+	936	WP_106649806.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
AYJ58_RS08795	1996398..1996808	-	411	WP_106649807.1	hypothetical protein	-
AYJ58_RS08800	1996845..1997102	-	258	WP_106649808.1	hypothetical protein	-
AYJ58_RS08805	1997220..1998680	-	1461	WP_106649809.1	site-specific integrase	-
AYJ58_RS08810	1998869..1999255	+	387	WP_157825773.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1972660..1998680	26020
	-	flank	IS/Tn	-	-	1990069..1991277	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-266)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 312 a.a.
• Molecular weight: 35387.22 Da
• Isoelectric Point: 6.7660

>T62604 WP_106649806.1 NZ_CP015194:1995344-1996279 [Shewanella sp. Pdp11]
MNKSSIYYQQVTLLIRMLPLVAQEKVFALKGGTAINLFVRNFPRLSVDIDLAYLPLEPREQALQSVKEALGRLTAQINLQ
PNLSAVFQDNKYDELRVVVTSDRVTIKIEVSPVARGTLHKAVLMPVVELVEEEFGYAEIPVVSLPDLYGGKLCAAMDRQH
PRDLFDVKMLLAEEGISREILVGFLTYTLSHPRPINEVMSPRWKPLDESFQTEFNGMTTKPIKLDELILTRSEMLIALQH
HFTAKDRDFLLSFKQGQPDWSLFDEPSVAALPAVRWKLLNIQNLAKNKSKHQEQLIKLADVLETWVTGRIL

Nucleotide

• Length: 936 bp

>T62604 NZ_CP015194:1995344-1996279 [Shewanella sp. Pdp11]
ATGAATAAGTCATCGATATACTACCAGCAAGTGACCTTGCTTATTCGGATGCTGCCGCTCGTCGCCCAAGAGAAGGTATT
TGCCCTAAAGGGCGGTACGGCTATCAACCTATTTGTGCGCAACTTCCCACGCTTATCGGTCGATATCGATTTGGCTTATC
TTCCTTTGGAGCCAAGGGAACAAGCGCTACAAAGTGTGAAGGAAGCGCTTGGTCGTTTGACTGCGCAGATCAATCTACAA
CCGAACCTTAGTGCAGTATTTCAAGACAATAAATATGATGAGCTCAGGGTTGTCGTGACAAGTGATAGAGTCACAATAAA
AATTGAAGTCTCTCCTGTTGCGAGAGGTACGCTACACAAAGCGGTATTAATGCCAGTCGTTGAGTTAGTTGAAGAAGAAT
TTGGGTATGCAGAGATCCCCGTTGTAAGCCTGCCTGATCTATACGGTGGTAAGTTATGTGCAGCGATGGATAGACAGCAC
CCAAGGGATCTTTTCGATGTGAAAATGCTGCTGGCGGAAGAGGGGATCAGTCGAGAGATTTTGGTCGGCTTTCTCACTTA
TACACTTAGCCATCCAAGGCCTATTAATGAAGTGATGTCTCCACGCTGGAAACCGCTTGATGAAAGCTTTCAAACTGAAT
TCAATGGAATGACGACAAAGCCGATTAAACTCGATGAGCTGATTTTAACTCGCTCAGAAATGCTGATAGCGTTGCAGCAT
CACTTTACTGCAAAAGACAGAGACTTTTTATTATCCTTTAAACAGGGTCAGCCTGATTGGTCATTGTTTGATGAACCGAG
CGTCGCGGCACTACCTGCGGTGAGATGGAAGCTATTGAATATCCAAAACCTAGCGAAAAACAAATCCAAGCATCAAGAAC
AACTCATTAAACTGGCTGATGTATTGGAAACGTGGGTTACAGGTCGGATACTCTAA

Antitoxin

Protein

• Length: 263 a.a.
• Molecular weight: 29868.96 Da
• Isoelectric Point: 9.3615

>AT62604 WP_106649805.1 NZ_CP015194:1994563-1995351 [Shewanella sp. Pdp11]
MSSKINWLINHTSPGAVVLQSWLTQNEISSSLVRKYVQSGWLYKISAGVYVRPESTGKLQPHWVEALKAVNEQLKLPVHL
AGVSSLTHQGLSHYLQLSSEQVWVGCQSKQALPKWFRELEEQNWLFYTSSKLTQTLEKDFITIGVNNREVKASCAELAAY
EVVNAIGKHISFEHAAELFQGLVNLSPRKIQSILNRSEAVQANRVFLFLGHYYQHQWSKRLDEQQITLGAGKRQVVAHGR
YDGRYQITVPASFIKTEENQYE

Nucleotide

• Length: 789 bp

>AT62604 NZ_CP015194:1994563-1995351 [Shewanella sp. Pdp11]
ATGTCATCAAAAATAAACTGGCTGATTAATCATACGAGTCCTGGTGCGGTAGTGCTTCAGTCGTGGTTGACACAAAATGA
GATCAGCTCATCTTTGGTGAGAAAATATGTGCAGAGTGGTTGGTTGTACAAGATAAGTGCGGGGGTTTACGTTCGTCCTG
AGTCAACAGGCAAGTTACAGCCTCATTGGGTTGAAGCGCTCAAGGCTGTGAATGAGCAGCTAAAGCTTCCTGTTCACCTT
GCGGGAGTCAGTAGCCTAACGCATCAAGGGCTTAGTCATTATCTTCAACTAAGCAGCGAGCAAGTTTGGGTTGGCTGTCA
AAGTAAGCAGGCGTTGCCAAAGTGGTTCCGCGAATTGGAGGAGCAAAATTGGCTTTTCTATACCAGTAGCAAGCTGACTC
AAACGTTGGAAAAAGACTTTATTACTATAGGGGTGAACAATAGGGAAGTTAAGGCAAGTTGTGCGGAGCTTGCAGCCTAT
GAGGTCGTCAATGCCATTGGCAAACATATCAGTTTTGAGCATGCCGCGGAGCTGTTTCAAGGGTTAGTGAATCTCAGCCC
ACGTAAAATACAGTCAATACTGAATCGAAGTGAAGCCGTACAAGCTAATCGCGTATTTCTCTTTTTAGGCCACTACTATC
AACACCAGTGGAGCAAAAGGCTAGATGAGCAGCAAATCACGCTAGGCGCGGGAAAGCGTCAGGTGGTGGCTCATGGCCGT
TACGATGGGCGGTATCAAATAACAGTGCCGGCATCGTTTATTAAGACAGAAGAAAATCAATATGAATAA