Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1932488..1933119 Replicon chromosome
Accession NZ_CP015193
Organism Thermococcus chitonophagus strain GC74

Toxin (Protein)


Gene name vapC Uniprot ID A0A161KEJ7
Locus tag A3L04_RS10700 Protein ID WP_068577956.1
Coordinates 1932488..1932895 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A160VTP4
Locus tag A3L04_RS10705 Protein ID WP_068577958.1
Coordinates 1932883..1933119 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L04_RS10670 (A3L04_10595) 1927653..1928645 + 993 WP_068577950.1 hypothetical protein -
A3L04_RS10675 (A3L04_10600) 1928614..1929366 - 753 WP_068577952.1 hypothetical protein -
A3L04_RS10685 (A3L04_10610) 1929855..1931117 - 1263 WP_068577954.1 ATP-binding protein -
A3L04_RS11345 (A3L04_10615) 1931173..1931355 - 183 WP_231963761.1 hypothetical protein -
A3L04_RS11350 (A3L04_10620) 1931749..1931937 - 189 WP_231963762.1 hypothetical protein -
A3L04_RS10700 (A3L04_10630) 1932488..1932895 - 408 WP_068577956.1 PIN domain-containing protein Toxin
A3L04_RS10705 (A3L04_10635) 1932883..1933119 - 237 WP_068577958.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A3L04_RS10710 (A3L04_10640) 1933550..1933819 + 270 WP_068577963.1 hypothetical protein -
A3L04_RS10715 (A3L04_10645) 1933816..1934157 - 342 WP_068577965.1 cupin domain-containing protein -
A3L04_RS10725 (A3L04_10655) 1934476..1934682 - 207 WP_068577968.1 hypothetical protein -
A3L04_RS10735 (A3L04_10660) 1934840..1935565 - 726 WP_068577970.1 tRNA-binding protein -
A3L04_RS11085 1935649..1935920 + 272 Protein_2128 4Fe-4S dicluster domain-containing protein -
A3L04_RS11150 (A3L04_10665) 1935894..1937408 + 1515 Protein_2129 aldehyde ferredoxin oxidoreductase C-terminal domain-containing protein -
A3L04_RS10745 (A3L04_10670) 1937478..1937732 + 255 WP_068577972.1 MoaD/ThiS family protein -
A3L04_RS10750 (A3L04_10675) 1937713..1938048 - 336 WP_068577975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(3-44)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15568.29 Da        Isoelectric Point: 9.8636

>T62601 WP_068577956.1 NZ_CP015193:c1932895-1932488 [Thermococcus chitonophagus]
MGSLAVIDTNVLIYSINKRSERYREARKILESLDELIIPVVVVYEFIWNLAEFGISSKVAKDVLSRILLDPRVKLVDDRK
HLLPTFEKLGGLSLRHYNDSMILRVAEEFGTLATYDRKLRKRAKKLGIDLLPENI

Download         Length: 408 bp

>T62601 NZ_CP015193:c1932895-1932488 [Thermococcus chitonophagus]
ATGGGAAGTTTAGCTGTTATTGACACGAACGTCCTTATATACTCAATAAACAAAAGGTCTGAAAGATACAGGGAAGCTAG
GAAAATTCTAGAGAGCCTTGATGAGCTAATAATTCCTGTTGTTGTAGTATATGAGTTCATATGGAACTTAGCTGAATTTG
GAATTTCATCGAAAGTTGCTAAAGATGTTCTTTCTCGGATTCTTCTTGATCCCAGGGTGAAATTAGTTGATGATAGGAAG
CATTTATTGCCCACATTTGAAAAATTGGGAGGTCTTAGCTTGAGGCATTATAATGATTCAATGATATTAAGGGTGGCTGA
GGAATTCGGAACTTTAGCCACCTATGATAGAAAATTGAGAAAAAGAGCCAAAAAACTTGGGATAGATTTACTTCCAGAGA
ATATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9071.51 Da        Isoelectric Point: 5.1972

>AT62601 WP_068577958.1 NZ_CP015193:c1933119-1932883 [Thermococcus chitonophagus]
MPITKVTRNYQITIPAEIRKALGIKMGEYLKVELRGDEIVIKRIDKEWPSIDLGRDFSPEDIEENIRKALSEASKWEV

Download         Length: 237 bp

>AT62601 NZ_CP015193:c1933119-1932883 [Thermococcus chitonophagus]
ATGCCAATAACAAAGGTCACGAGAAACTATCAAATTACAATACCAGCTGAGATTCGAAAAGCTTTGGGGATTAAGATGGG
GGAATACCTCAAAGTTGAATTGAGAGGAGATGAGATAGTCATTAAGAGGATAGACAAGGAATGGCCAAGTATAGACCTCG
GTAGAGATTTCTCTCCAGAAGATATCGAAGAGAACATAAGGAAAGCTCTCTCGGAGGCCTCAAAATGGGAAGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161KEJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A160VTP4

References