Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1519860..1520337 Replicon chromosome
Accession NZ_CP015173
Organism Staphylococcus aureus strain RIVM6519

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag A5J11_RS07515 Protein ID WP_000052076.1
Coordinates 1519860..1520048 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A5J11_RS07520 Protein ID WP_001059690.1
Coordinates 1520077..1520337 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5J11_RS07485 1515854..1516375 + 522 WP_000824482.1 hypothetical protein -
A5J11_RS07490 1516716..1517402 + 687 WP_000141557.1 thermonuclease family protein -
A5J11_RS07495 1517759..1517959 + 201 WP_001059082.1 cold-shock protein -
A5J11_RS07500 1518451..1518669 - 219 WP_000005886.1 hypothetical protein -
A5J11_RS07505 1518731..1519015 - 285 WP_001004399.1 hypothetical protein -
A5J11_RS07510 1519103..1519672 - 570 WP_001106654.1 hypothetical protein -
A5J11_RS07515 1519860..1520048 - 189 WP_000052076.1 hypothetical protein Toxin
A5J11_RS07520 1520077..1520337 - 261 WP_001059690.1 hypothetical protein Antitoxin
A5J11_RS07525 1520678..1520881 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A5J11_RS07530 1520878..1521114 - 237 WP_000349581.1 hypothetical protein -
A5J11_RS07535 1521339..1521920 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
A5J11_RS07540 1521993..1522610 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
A5J11_RS07545 1522765..1523259 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
A5J11_RS07550 1523658..1524080 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
A5J11_RS07555 1524228..1524944 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(28-89)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T62587 WP_000052076.1 NZ_CP015173:c1520048-1519860 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T62587 NZ_CP015173:c1520048-1519860 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT62587 WP_001059690.1 NZ_CP015173:c1520337-1520077 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT62587 NZ_CP015173:c1520337-1520077 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References