Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 172464..173092 Replicon plasmid unnamed1
Accession NZ_CP015169
Organism Acetobacter ascendens strain LMG 1591

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A4R89_RS14650 Protein ID WP_070325489.1
Coordinates 172688..173092 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C7JJ36
Locus tag A4R89_RS14645 Protein ID WP_012813340.1
Coordinates 172464..172688 (+) Length 75 a.a.

Genomic Context

A4R89_RS14620A4R89_RS14635A4R89_RS14640A4R89_RS14645A4R89_RS14650A4R89_RS16640A4R89_RS14655A4R89_RS16645A4R89_RS14660A4R89_RS17265A4R89_RS17270A4R89_RS14665A4R89_RS14670
Location: 167578..168963 (1386 bp)
Type: Others
Protein ID: WP_070325487.1
Location: 170392..170802 (411 bp)
Type: Others
Protein ID: Protein_166
Location: 170925..172358 (1434 bp)
Type: Others
Protein ID: WP_029604385.1
Location: 172464..172688 (225 bp)
Type: Antitoxin
Protein ID: WP_012813340.1
Location: 172688..173092 (405 bp)
Type: Toxin
Protein ID: WP_070325489.1
Location: 173300..173386 (87 bp)
Type: Others
Protein ID: Protein_170
Location: 173482..174867 (1386 bp)
Type: Others
Protein ID: WP_070324433.1
Location: 174999..175169 (171 bp)
Type: Others
Protein ID: WP_082247085.1
Location: 175170..175475 (306 bp)
Type: Others
Protein ID: WP_012813344.1
Location: 169387..170058 (672 bp)
Type: Others
Protein ID: WP_082247084.1
Location: 170055..170324 (270 bp)
Type: Others
Protein ID: WP_070325488.1
Location: 175608..176441 (834 bp)
Type: Others
Protein ID: WP_070325490.1
Location: 176410..177267 (858 bp)
Type: Others
Protein ID: WP_070325491.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A4R89_RS14620167578..168963+1386WP_070325487.1IS1380 family transposase-
A4R89_RS17265169387..170058-672WP_082247084.1IS3 family transposase-
A4R89_RS17270170055..170324-270WP_070325488.1transposase-
A4R89_RS14635170392..170802+411Protein_166hypothetical protein-
A4R89_RS14640170925..172358+1434WP_029604385.1hypothetical protein-
A4R89_RS14645172464..172688+225WP_012813340.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
A4R89_RS14650172688..173092+405WP_070325489.1tRNA(fMet)-specific endonuclease VapCToxin
A4R89_RS16640173300..173386+87Protein_170type II toxin-antitoxin system CcdA family antitoxin-
A4R89_RS14655173482..174867+1386WP_070324433.1IS1380 family transposase-
A4R89_RS16645174999..175169+171WP_082247085.1type II toxin-antitoxin system CcdA family antitoxin-
A4R89_RS14660175170..175475+306WP_012813344.1CcdB family protein-
A4R89_RS14665175608..176441-834WP_070325490.1TIGR02391 family protein-
A4R89_RS14670176410..177267-858WP_070325491.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..259464259464
-insideIScluster/Tn--161233..17486713634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(9-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15180.32 Da        Isoelectric Point: 6.0964

>T62576 WP_070325489.1 NZ_CP015169:172688-173092 [Acetobacter ascendens]
MLRYLLDTNFCIRVLRDRPQGLRERFNDNAEALCISDVVLYELLYGAEKSHDPAKIRREVEHFAARLSVLPFDDDAAAHT
AEIRVELEKRGCVIGPYDLMIAGHARSRGLVVVTGNLRELTRVDGLRSEDWTAG

Download         Length: 405 bp

>T62576 NZ_CP015169:172688-173092 [Acetobacter ascendens]
ATGCTTCGTTATCTTCTGGATACAAACTTTTGCATTCGTGTCCTGCGTGATCGTCCGCAAGGCTTGCGTGAGCGTTTCAA
TGATAACGCCGAGGCGCTCTGCATCTCGGATGTCGTGCTTTACGAACTTCTCTATGGAGCCGAAAAATCTCACGATCCGG
CAAAGATTCGACGTGAGGTTGAGCATTTTGCCGCACGTCTGTCTGTTTTGCCGTTTGATGATGACGCCGCAGCCCATACA
GCGGAAATCAGGGTAGAGCTGGAAAAGCGTGGCTGTGTCATCGGCCCATACGATTTGATGATTGCCGGGCACGCTCGAAG
CAGGGGGCTTGTCGTTGTGACTGGAAACTTACGAGAACTTACGAGGGTAGATGGGTTGCGATCTGAGGATTGGACGGCCG
GTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8310.55 Da        Isoelectric Point: 8.9793

>AT62576 WP_012813340.1 NZ_CP015169:172464-172688 [Acetobacter ascendens]
MLTRTTLFLSNRSQAVRLPKAVAFDVNLKDVVIIPDGARRIIAPANAAWDDFFAAPGTPLPERDQPRMQERESF

Download         Length: 225 bp

>AT62576 NZ_CP015169:172464-172688 [Acetobacter ascendens]
ATGCTCACCCGCACGACGCTCTTTCTGTCCAATCGCTCCCAGGCCGTGCGTCTTCCCAAAGCGGTTGCATTTGACGTCAA
CCTGAAAGACGTCGTGATCATCCCGGACGGTGCGCGTCGTATAATCGCACCTGCAAATGCCGCATGGGACGATTTCTTTG
CCGCGCCGGGCACTCCACTGCCTGAGCGTGATCAGCCGAGGATGCAGGAACGCGAAAGCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A511FS67

References