Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 11725..12404 Replicon plasmid unnamed1
Accession NZ_CP015169
Organism Acetobacter ascendens strain LMG 1591

Toxin (Protein)


Gene name vapC Uniprot ID A0A401X8K4
Locus tag A4R89_RS13885 Protein ID WP_042788834.1
Coordinates 11994..12404 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A4R89_RS13880 Protein ID WP_211274216.1
Coordinates 11725..11997 (+) Length 91 a.a.

Genomic Context

A4R89_RS13855A4R89_RS13860A4R89_RS13865A4R89_RS13870A4R89_RS13875A4R89_RS13880A4R89_RS13885A4R89_RS16555A4R89_RS13910A4R89_RS13895A4R89_RS13900A4R89_RS13905A4R89_RS13915
Location: 6900..8285 (1386 bp)
Type: Others
Protein ID: WP_070325411.1
Location: 8778..9458 (681 bp)
Type: Others
Protein ID: WP_070325412.1
Location: 10253..10741 (489 bp)
Type: Others
Protein ID: WP_070325413.1
Location: 10804..11241 (438 bp)
Type: Others
Protein ID: WP_070325414.1
Location: 11238..11654 (417 bp)
Type: Others
Protein ID: WP_070325415.1
Location: 11725..11997 (273 bp)
Type: Antitoxin
Protein ID: WP_211274216.1
Location: 11994..12404 (411 bp)
Type: Toxin
Protein ID: WP_042788834.1
Location: 12752..12961 (210 bp)
Type: Others
Protein ID: WP_082247097.1
Location: 14899..16284 (1386 bp)
Type: Others
Protein ID: WP_070324433.1
Location: 13211..13564 (354 bp)
Type: Others
Protein ID: WP_081273974.1
Location: 13624..14427 (804 bp)
Type: Others
Protein ID: WP_070325416.1
Location: 14524..14805 (282 bp)
Type: Others
Protein ID: Protein_19
Location: 16469..16657 (189 bp)
Type: Others
Protein ID: Protein_21
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A4R89_RS138556900..8285+1386WP_070325411.1IS1380 family transposase-
A4R89_RS138608778..9458+681WP_070325412.1hypothetical protein-
A4R89_RS1386510253..10741+489WP_070325413.1single-stranded DNA-binding protein-
A4R89_RS1387010804..11241+438WP_070325414.1plasmid protein-
A4R89_RS1387511238..11654+417WP_070325415.1hypothetical protein-
A4R89_RS1388011725..11997+273WP_211274216.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
A4R89_RS1388511994..12404+411WP_042788834.1type II toxin-antitoxin system VapC family toxinToxin
A4R89_RS1655512752..12961+210WP_082247097.1hypothetical protein-
A4R89_RS1389513211..13564-354WP_081273974.1hypothetical protein-
A4R89_RS1390013624..14427-804WP_070325416.1hypothetical protein-
A4R89_RS1390514524..14805-282Protein_19hypothetical protein-
A4R89_RS1391014899..16284+1386WP_070324433.1IS1380 family transposase-
A4R89_RS1391516469..16657-189Protein_21hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..259464259464
-flankIS/Tn--14899..162841385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14843.13 Da        Isoelectric Point: 4.7037

>T62574 WP_042788834.1 NZ_CP015169:11994-12404 [Acetobacter ascendens]
VSTYLLDTNIISDLVRNPSGLCAQRIELIDPGDLCTSIIVAAELRYGCAKKGSAKLLNRVESVLAFIPVLPLDIPADGEY
GGIRAELEAAGQTIGMNDLLIAAHAYTLKATLVTNNTREFMRIRGLRLENWLENET

Download         Length: 411 bp

>T62574 NZ_CP015169:11994-12404 [Acetobacter ascendens]
GTGAGCACCTATCTTCTTGATACCAACATCATCAGTGATCTGGTTCGCAATCCTTCCGGCTTATGTGCGCAACGCATTGA
GCTTATCGACCCCGGCGACCTTTGCACCAGCATCATTGTGGCTGCTGAGTTGCGTTATGGATGCGCAAAAAAAGGCTCTG
CGAAGCTATTGAACCGGGTTGAGAGCGTGCTGGCTTTTATCCCCGTCCTGCCACTCGATATTCCTGCTGACGGTGAATAC
GGTGGCATCCGTGCCGAACTCGAAGCCGCAGGGCAGACGATCGGCATGAATGATCTGCTCATCGCGGCGCATGCCTACAC
CCTCAAGGCGACCCTGGTGACGAACAACACACGTGAGTTTATGCGTATCAGAGGCTTGAGGCTCGAAAATTGGCTGGAGA
ATGAGACGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10467.11 Da        Isoelectric Point: 4.8723

>AT62574 WP_211274216.1 NZ_CP015169:11725-11997 [Acetobacter ascendens]
MPVPKVTPRPREVKLFWNNRSQAVRIPVEFQMPGDRVLIHRDGEKLVLEPVKTPSTLKELLMAWREEPQLRPEDDFPDIQ
DVAATPEDIL

Download         Length: 273 bp

>AT62574 NZ_CP015169:11725-11997 [Acetobacter ascendens]
ATGCCAGTTCCTAAAGTGACTCCCCGACCACGCGAAGTAAAACTGTTCTGGAACAACCGCAGTCAGGCAGTGCGGATTCC
GGTTGAATTTCAAATGCCAGGAGACCGGGTGCTGATCCACCGTGACGGTGAGAAACTCGTTCTGGAGCCAGTGAAAACGC
CTTCTACGCTGAAGGAGCTTCTCATGGCATGGCGTGAAGAGCCGCAGCTCAGGCCCGAAGATGATTTTCCTGATATTCAG
GACGTTGCCGCCACACCGGAAGATATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A401X8K4

Antitoxin

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Source
ID
Structure
No matching records found

References