Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdB-relB/RelB(antitoxin)
Location 1059711..1060426 Replicon chromosome
Accession NZ_CP015164
Organism Acetobacter ascendens strain LMG 1590

Toxin (Protein)


Gene name ccdB Uniprot ID C7JJ41
Locus tag A4S02_RS05130 Protein ID WP_012813344.1
Coordinates 1060121..1060426 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5QDQ9
Locus tag A4S02_RS05125 Protein ID WP_003618686.1
Coordinates 1059711..1059971 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4S02_RS14890 1056031..1056979 - 949 Protein_994 IS630 family transposase -
A4S02_RS05110 1057343..1058027 - 685 Protein_995 DUF1275 domain-containing protein -
A4S02_RS05115 1058027..1059289 - 1263 WP_070323151.1 sodium:proton antiporter -
A4S02_RS05120 1059421..1059714 - 294 WP_070323152.1 type II toxin-antitoxin system RelE/ParE family toxin -
A4S02_RS05125 1059711..1059971 - 261 WP_003618686.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A4S02_RS05130 1060121..1060426 - 306 WP_012813344.1 CcdB family protein Toxin
A4S02_RS14895 1060427..1060627 - 201 WP_012813343.1 type II toxin-antitoxin system CcdA family antitoxin -
A4S02_RS05135 1060822..1061226 - 405 WP_003630720.1 tRNA(fMet)-specific endonuclease VapC -
A4S02_RS05140 1061226..1061450 - 225 WP_012813340.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
A4S02_RS05145 1061556..1062989 - 1434 WP_070323153.1 hypothetical protein -
A4S02_RS15600 1063001..1063498 + 498 WP_157885528.1 hypothetical protein -
A4S02_RS05155 1063514..1064596 + 1083 WP_208858931.1 IS5 family transposase -
A4S02_RS05160 1064713..1065048 + 336 Protein_1006 transposase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1050591..1073592 23001
- flank IS/Tn - - 1064767..1065048 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11328.32 Da        Isoelectric Point: 4.7106

>T62570 WP_012813344.1 NZ_CP015164:c1060426-1060121 [Acetobacter ascendens]
MARFDVYCLAGRGEARFVLDVQADLLDELGTRIVVPLLSQKVAPRPAKRLNPIFVVDDQSFVMMTQFMAAVPDRDLKKVV
TSLSLYQDEIIQAIDLLLTGF

Download         Length: 306 bp

>T62570 NZ_CP015164:c1060426-1060121 [Acetobacter ascendens]
ATGGCGCGTTTTGATGTGTATTGTTTGGCCGGACGAGGTGAAGCGCGTTTCGTTTTAGATGTGCAGGCAGACCTGCTTGA
CGAGTTGGGCACCCGCATTGTGGTGCCGCTTTTATCACAGAAAGTGGCACCCAGGCCGGCAAAGAGACTGAATCCGATTT
TCGTAGTCGATGACCAGTCGTTCGTTATGATGACACAGTTTATGGCTGCTGTACCTGACCGTGATCTGAAAAAAGTCGTG
ACGTCATTGTCTCTTTATCAGGATGAAATCATCCAGGCTATTGATCTACTTTTAACTGGTTTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9762.23 Da        Isoelectric Point: 10.4645

>AT62570 WP_003618686.1 NZ_CP015164:c1059971-1059711 [Acetobacter ascendens]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Download         Length: 261 bp

>AT62570 NZ_CP015164:c1059971-1059711 [Acetobacter ascendens]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401X741

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3T9M6

References