Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3673033..3673604 Replicon chromosome
Accession NZ_CP015163
Organism Amycolatopsis albispora strain WP1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag A4R43_RS17045 Protein ID WP_205215493.1
Coordinates 3673033..3673383 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag A4R43_RS17050 Protein ID WP_113693232.1
Coordinates 3673380..3673604 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R43_RS17025 3668901..3670235 + 1335 WP_113693227.1 DUF349 domain-containing protein -
A4R43_RS17030 3670481..3670945 - 465 WP_162788499.1 FCD domain-containing protein -
A4R43_RS17035 3671052..3671528 - 477 WP_113693229.1 hypothetical protein -
A4R43_RS17040 3671525..3672988 - 1464 WP_113693230.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
A4R43_RS17045 3673033..3673383 - 351 WP_205215493.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A4R43_RS17050 3673380..3673604 - 225 WP_113693232.1 ribbon-helix-helix protein, CopG family Antitoxin
A4R43_RS17055 3673718..3674626 + 909 WP_113693233.1 TAXI family TRAP transporter solute-binding subunit -
A4R43_RS17060 3674616..3676019 - 1404 WP_113693234.1 HAMP domain-containing histidine kinase -
A4R43_RS17065 3676023..3676697 - 675 WP_113693235.1 response regulator transcription factor -
A4R43_RS17070 3676939..3677667 + 729 WP_205215494.1 ATP-binding cassette domain-containing protein -
A4R43_RS17075 3677684..3678526 + 843 WP_113693237.1 glutamate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.58 Da        Isoelectric Point: 11.7576

>T62568 WP_205215493.1 NZ_CP015163:c3673383-3673033 [Amycolatopsis albispora]
MMRRAEIRLVDLDPARGSESNKTRPAVIVSNDGANVMAGRLGRGVVTVVPVTSNVRRVFPFQVLLPAAECGLAVDSKAQA
EQVRSVSVERVGRRAGKLTPALMERLDAALRLHLGL

Download         Length: 351 bp

>T62568 NZ_CP015163:c3673383-3673033 [Amycolatopsis albispora]
CTGATGCGGCGGGCCGAGATCCGGCTGGTCGACCTCGACCCCGCGCGGGGCAGCGAGTCGAACAAGACCAGGCCGGCGGT
GATCGTGAGCAACGACGGCGCGAACGTGATGGCCGGGCGGCTGGGCCGCGGGGTGGTGACCGTGGTGCCGGTGACCTCGA
ACGTGCGCCGGGTGTTCCCGTTCCAGGTGCTGCTGCCCGCCGCCGAGTGCGGGCTGGCGGTGGATTCGAAGGCGCAGGCC
GAGCAGGTCAGGTCGGTTTCGGTGGAGCGGGTGGGCCGCCGGGCAGGCAAGCTGACGCCCGCGCTGATGGAGCGCCTCGA
CGCCGCGCTGCGCCTGCATCTCGGGCTGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8155.92 Da        Isoelectric Point: 4.3039

>AT62568 WP_113693232.1 NZ_CP015163:c3673604-3673380 [Amycolatopsis albispora]
MKLSVSLSDEDVAFIDHYAAAAHVPSRSAVVHRALELLRASQLEDDYRAAWDEWAARGDEAEWDAATGDGVLTR

Download         Length: 225 bp

>AT62568 NZ_CP015163:c3673604-3673380 [Amycolatopsis albispora]
ATGAAATTGAGCGTCAGCCTGTCGGACGAGGACGTGGCCTTCATCGACCACTACGCCGCCGCGGCGCACGTTCCGTCGCG
CTCCGCGGTGGTCCACCGCGCGCTGGAGCTGCTGCGGGCCAGCCAGCTGGAGGACGACTACCGGGCCGCGTGGGACGAGT
GGGCCGCCCGCGGGGACGAGGCCGAATGGGACGCCGCCACCGGTGACGGGGTGCTGACCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References