Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3673405..3674236 Replicon chromosome
Accession NZ_CP015159
Organism Escherichia coli strain Eco889

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag WM90_RS18515 Protein ID WP_000854814.1
Coordinates 3673862..3674236 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag WM90_RS18510 Protein ID WP_001546021.1
Coordinates 3673405..3673773 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM90_RS18475 3668462..3669532 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
WM90_RS18480 3669668..3670345 + 678 WP_001362823.1 hypothetical protein -
WM90_RS18485 3670361..3670771 + 411 WP_000846704.1 hypothetical protein -
WM90_RS18490 3670992..3671813 + 822 WP_001234710.1 DUF945 domain-containing protein -
WM90_RS18495 3672076..3672549 + 474 WP_001385393.1 antirestriction protein -
WM90_RS18500 3672565..3673041 + 477 WP_001186773.1 RadC family protein -
WM90_RS18505 3673104..3673325 + 222 WP_000692323.1 DUF987 domain-containing protein -
WM90_RS18510 3673405..3673773 + 369 WP_001546021.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
WM90_RS18515 3673862..3674236 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
WM90_RS18520 3674233..3674427 + 195 WP_000988601.1 hypothetical protein -
WM90_RS30035 3674440..3674553 + 114 WP_001161660.1 DUF957 domain-containing protein -
WM90_RS18530 3674916..3675662 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
WM90_RS18535 3675677..3677218 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
WM90_RS28005 3677429..3677575 - 147 Protein_3512 transposase domain-containing protein -
WM90_RS18540 3677629..3677811 + 183 WP_001016348.1 hypothetical protein -
WM90_RS18545 3677912..3678241 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T62544 WP_000854814.1 NZ_CP015159:3673862-3674236 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T62544 NZ_CP015159:3673862-3674236 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT62544 WP_001546021.1 NZ_CP015159:3673405-3673773 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT62544 NZ_CP015159:3673405-3673773 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References