Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402193..2402722 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name parE Uniprot ID P9WHG5
Locus tag Rv2142c Protein ID NP_216658.1
Coordinates 2402193..2402510 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ75
Locus tag Rv2142A Protein ID YP_007410825.1
Coordinates 2402507..2402722 (-) Length 72 a.a.

Genomic Context

Rv2138Rv2139Rv2143Rv2140cRv2141cRv2142cRv2142ARv2144cRv2145cRv2146cRv2147cRv2148c
Location: 2397330..2398406 (1077 bp)
Type: Others
Protein ID: NP_216654.1
Location: 2398720..2399793 (1074 bp)
Type: Others
Protein ID: NP_216655.1
Location: 2402977..2404035 (1059 bp)
Type: Others
Protein ID: NP_216659.1
Location: 2399798..2400328 (531 bp)
Type: Others
Protein ID: NP_216656.1
Location: 2400376..2401722 (1347 bp)
Type: Others
Protein ID: YP_177864.1
Location: 2402193..2402510 (318 bp)
Type: Toxin
Protein ID: NP_216658.1
Location: 2402507..2402722 (216 bp)
Type: Antitoxin
Protein ID: YP_007410825.1
Location: 2404165..2404521 (357 bp)
Type: Others
Protein ID: NP_216660.1
Location: 2404616..2405398 (783 bp)
Type: Others
Protein ID: NP_216661.1
Location: 2405666..2405956 (291 bp)
Type: Others
Protein ID: NP_216662.1
Location: 2406118..2406843 (726 bp)
Type: Others
Protein ID: NP_216663.1
Location: 2406840..2407616 (777 bp)
Type: Others
Protein ID: NP_216664.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv21382397330..2398406+1077NP_216654.1lipoprotein LppL-
Rv21392398720..2399793+1074NP_216655.1dihydroorotate dehydrogenase-
Rv2140c2399798..2400328-531NP_216656.1hypothetical protein-
Rv2141c2400376..2401722-1347YP_177864.1hypothetical protein-
Rv2142c2402193..2402510-318NP_216658.1toxin ParE2Toxin
Rv2142A2402507..2402722-216YP_007410825.1antitoxin ParD2Antitoxin
Rv21432402977..2404035+1059NP_216659.1hypothetical protein-
Rv2144c2404165..2404521-357NP_216660.1transmembrane protein-
Rv2145c2404616..2405398-783NP_216661.1cell wall synthesis protein Wag31-
Rv2146c2405666..2405956-291NP_216662.1transmembrane protein-
Rv2147c2406118..2406843-726NP_216663.1cell division protein SepF-
Rv2148c2406840..2407616-777NP_216664.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T6249 NP_216658.1 NC_000962:c2402510-2402193 [Mycobacterium tuberculosis H37Rv]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T6249 NC_000962:c2402510-2402193 [Mycobacterium tuberculosis H37Rv]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT6249 YP_007410825.1 NC_000962:c2402722-2402507 [Mycobacterium tuberculosis H37Rv]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT6249 NC_000962:c2402722-2402507 [Mycobacterium tuberculosis H37Rv]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBP9WHG5

Antitoxin

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Source
ID
Structure
AlphaFold DBP9WJ75

References

(1) Amita Gupta (2009) Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS Microbiology Letters 290(1):45-53. [PubMed:19016878] experimental

(2) Manish Gupta et al. (2016) The Chromosomal parDE2 Toxin-Antitoxin System of Mycobacterium tuberculosis H37Rv: Genetic and Functional Characterization. Frontiers in Microbiology 7:886. [PubMed:27379032] experimental


experimental experimental literature