62485

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3812466..3813297 Replicon chromosome
Accession NZ_CP015138
Organism Escherichia coli strain Ecol_732

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag A4X18_RS18600 Protein ID WP_000854815.1
Coordinates 3812466..3812840 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag A4X18_RS18605 Protein ID WP_001280918.1
Coordinates 3812929..3813297 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4X18_RS18560 3807862..3809028 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
A4X18_RS18565 3809147..3809620 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
A4X18_RS18570 3809818..3810876 + 1059 WP_001200889.1 FUSC family protein -
A4X18_RS18575 3811048..3811377 + 330 WP_000450409.1 DUF496 family protein -
A4X18_RS18580 3811478..3811660 - 183 WP_001296208.1 hypothetical protein -
A4X18_RS18585 3811714..3811860 + 147 Protein_3523 transposase domain-containing protein -
A4X18_RS30730 3812149..3812262 - 114 WP_001161660.1 DUF957 domain-containing protein -
A4X18_RS18595 3812275..3812469 - 195 WP_000988600.1 hypothetical protein -
A4X18_RS18600 3812466..3812840 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
A4X18_RS18605 3812929..3813297 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A4X18_RS18610 3813313..3813957 - 645 WP_000086752.1 hypothetical protein -
A4X18_RS18615 3813976..3814197 - 222 WP_000692345.1 DUF987 domain-containing protein -
A4X18_RS18620 3814260..3814736 - 477 WP_001186200.1 RadC family protein -
A4X18_RS18625 3814752..3815225 - 474 WP_001542276.1 antirestriction protein -
A4X18_RS18630 3815319..3815564 - 246 WP_001164966.1 hypothetical protein -
A4X18_RS18635 3815564..3816382 - 819 WP_001542275.1 DUF945 domain-containing protein -
A4X18_RS18640 3816603..3817013 - 411 WP_000846703.1 hypothetical protein -
A4X18_RS18645 3817029..3817379 - 351 Protein_3535 hypothetical protein -
A4X18_RS18650 3817462..3818208 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T62485 WP_000854815.1 NZ_CP015138:c3812840-3812466 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T62485 NZ_CP015138:c3812840-3812466 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT62485 WP_001280918.1 NZ_CP015138:c3813297-3812929 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT62485 NZ_CP015138:c3813297-3812929 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References