62482

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2831201..2831855 Replicon chromosome
Accession NZ_CP015138
Organism Escherichia coli strain Ecol_732

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag A4X18_RS14015 Protein ID WP_000244765.1
Coordinates 2831448..2831855 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag A4X18_RS14010 Protein ID WP_000354050.1
Coordinates 2831201..2831467 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4X18_RS13990 2827289..2828722 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
A4X18_RS13995 2828767..2829078 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
A4X18_RS14000 2829242..2829901 + 660 WP_000250275.1 hemolysin III family protein -
A4X18_RS14005 2829978..2830958 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
A4X18_RS14010 2831201..2831467 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
A4X18_RS14015 2831448..2831855 + 408 WP_000244765.1 protein YgfX Toxin
A4X18_RS14020 2831895..2832416 - 522 WP_001055874.1 flavodoxin FldB -
A4X18_RS14025 2832528..2833424 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
A4X18_RS14030 2833449..2834159 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A4X18_RS14035 2834165..2835898 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T62482 WP_000244765.1 NZ_CP015138:2831448-2831855 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T62482 NZ_CP015138:2831448-2831855 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT62482 WP_000354050.1 NZ_CP015138:2831201-2831467 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT62482 NZ_CP015138:2831201-2831467 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References