Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2685332..2686166 | Replicon | chromosome |
| Accession | NZ_CP015138 | ||
| Organism | Escherichia coli strain Ecol_732 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | A4X18_RS13185 | Protein ID | WP_000854690.1 |
| Coordinates | 2685332..2685709 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | A4X18_RS13190 | Protein ID | WP_001305076.1 |
| Coordinates | 2685798..2686166 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A4X18_RS31120 | 2681726..2681881 | - | 156 | WP_000729638.1 | hypothetical protein | - |
| A4X18_RS13160 | 2682313..2683246 | - | 934 | Protein_2493 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| A4X18_RS13165 | 2683239..2683634 | - | 396 | WP_000208384.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| A4X18_RS13170 | 2683703..2684548 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| A4X18_RS13175 | 2684633..2684830 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| A4X18_RS13180 | 2684847..2685335 | - | 489 | WP_000761699.1 | hypothetical protein | - |
| A4X18_RS13185 | 2685332..2685709 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| A4X18_RS13190 | 2685798..2686166 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| A4X18_RS13195 | 2686216..2686860 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| A4X18_RS13200 | 2686879..2687100 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| A4X18_RS13205 | 2687163..2687639 | - | 477 | WP_001186726.1 | RadC family protein | - |
| A4X18_RS13210 | 2687655..2688140 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| A4X18_RS13215 | 2688195..2689013 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| A4X18_RS13220 | 2689114..2689347 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
| A4X18_RS13225 | 2689426..2689881 | - | 456 | WP_000581502.1 | hypothetical protein | - |
| A4X18_RS13230 | 2689957..2691084 | - | 1128 | Protein_2507 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / sat | 2665782..2731838 | 66056 | |
| - | flank | IS/Tn | - | - | 2681726..2681881 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T62481 WP_000854690.1 NZ_CP015138:c2685709-2685332 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T62481 NZ_CP015138:c2685709-2685332 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT62481 WP_001305076.1 NZ_CP015138:c2686166-2685798 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT62481 NZ_CP015138:c2686166-2685798 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAATAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAATAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|