Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4877140..4877735 Replicon chromosome
Accession NZ_CP015137
Organism Dickeya solani IPO 2222

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag A4U42_RS20865 Protein ID WP_013318177.1
Coordinates 4877140..4877517 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag A4U42_RS20870 Protein ID WP_022633800.1
Coordinates 4877514..4877735 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U42_RS20850 4872806..4873072 + 267 WP_022633797.1 hypothetical protein -
A4U42_RS22030 4873304..4873486 + 183 WP_072142890.1 hypothetical protein -
A4U42_RS20855 4873568..4875334 - 1767 WP_022633798.1 ATP-binding protein -
A4U42_RS20860 4875324..4876502 - 1179 WP_022633799.1 hypothetical protein -
A4U42_RS20865 4877140..4877517 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
A4U42_RS20870 4877514..4877735 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A4U42_RS20875 4877876..4879024 - 1149 WP_022633801.1 L-threonine dehydrogenase -
A4U42_RS20880 4879306..4879866 + 561 WP_026594485.1 NUDIX domain-containing protein -
A4U42_RS20885 4879938..4880615 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
A4U42_RS20890 4880615..4881334 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T62468 WP_013318177.1 NZ_CP015137:c4877517-4877140 [Dickeya solani IPO 2222]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

>T62468 NZ_CP015137:c4877517-4877140 [Dickeya solani IPO 2222]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGCCGCAATGGCATATTGATTGTCGATAACGATAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT62468 WP_022633800.1 NZ_CP015137:c4877735-4877514 [Dickeya solani IPO 2222]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp

>AT62468 NZ_CP015137:c4877735-4877514 [Dickeya solani IPO 2222]
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAATATTGCGACAGTCATTGATACGGCGGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACCTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAGATTAGACG
CTGAATTCGATTTCATCATGCAGCGCCACGGACACACAATCAAAGCGCTCGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References