Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3927811..3928428 Replicon chromosome
Accession NZ_CP015137
Organism Dickeya solani IPO 2222

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag A4U42_RS21420 Protein ID WP_012764944.1
Coordinates 3928249..3928428 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag A4U42_RS16850 Protein ID WP_022633005.1
Coordinates 3927811..3928221 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U42_RS16825 3923311..3924228 + 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -
A4U42_RS16830 3924225..3925247 + 1023 WP_022633001.1 iron ABC transporter permease -
A4U42_RS16835 3925240..3926289 + 1050 WP_022633002.1 iron ABC transporter permease -
A4U42_RS16840 3926301..3927146 + 846 WP_023637730.1 ABC transporter ATP-binding protein -
A4U42_RS16845 3927143..3927808 + 666 WP_022633004.1 RraA family protein -
A4U42_RS16850 3927811..3928221 - 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4U42_RS21420 3928249..3928428 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
A4U42_RS21425 3928750..3929112 + 363 WP_071598627.1 hypothetical protein -
A4U42_RS16855 3929448..3930503 - 1056 WP_022633006.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T62457 WP_012764944.1 NZ_CP015137:c3928428-3928249 [Dickeya solani IPO 2222]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T62457 NZ_CP015137:c3928428-3928249 [Dickeya solani IPO 2222]
ATGGACAGCAGGACGCTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT62457 WP_022633005.1 NZ_CP015137:c3928221-3927811 [Dickeya solani IPO 2222]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp

>AT62457 NZ_CP015137:c3928221-3927811 [Dickeya solani IPO 2222]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCATGCCTACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGACGCGATCACCGGCCATATCGAGCTGCTGATCGAGA
TGGGTCAGGATATTCCTGCTGTGTCATCAGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCAGAGAAAATTAATGTCACGTTGCCGAAATCGCTGATTGACCGTAT
TGACCGTTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References