Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3382781..3383406 Replicon chromosome
Accession NZ_CP015137
Organism Dickeya solani IPO 2222

Toxin (Protein)


Gene name Hha Uniprot ID A0A2K8W3K4
Locus tag A4U42_RS14615 Protein ID WP_022632574.1
Coordinates 3382781..3382984 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8W3I1
Locus tag A4U42_RS14620 Protein ID WP_022632575.1
Coordinates 3383038..3383406 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U42_RS14585 3378421..3378759 + 339 WP_002208627.1 P-II family nitrogen regulator -
A4U42_RS14590 3378802..3380094 + 1293 WP_022632570.1 ammonium transporter AmtB -
A4U42_RS14595 3380190..3381053 - 864 WP_022632571.1 acyl-CoA thioesterase II -
A4U42_RS14600 3381305..3381862 + 558 WP_022632572.1 YbaY family lipoprotein -
A4U42_RS14605 3381891..3382220 - 330 WP_022632573.1 MGMT family protein -
A4U42_RS14615 3382781..3382984 - 204 WP_022632574.1 hemolysin expression modulator Hha Toxin
A4U42_RS14620 3383038..3383406 - 369 WP_022632575.1 Hha toxicity modulator TomB Antitoxin
A4U42_RS21375 3383914..3384057 - 144 WP_022632576.1 type B 50S ribosomal protein L36 -
A4U42_RS14625 3384073..3384324 - 252 WP_022632577.1 type B 50S ribosomal protein L31 -
A4U42_RS14630 3384501..3387647 - 3147 WP_022632578.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.52 Da        Isoelectric Point: 8.8580

>T62455 WP_022632574.1 NZ_CP015137:c3382984-3382781 [Dickeya solani IPO 2222]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T62455 NZ_CP015137:c3382984-3382781 [Dickeya solani IPO 2222]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGATCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAGATACGTTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14223.06 Da        Isoelectric Point: 5.1663

>AT62455 WP_022632575.1 NZ_CP015137:c3383406-3383038 [Dickeya solani IPO 2222]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT62455 NZ_CP015137:c3383406-3383038 [Dickeya solani IPO 2222]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCATGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATCAATGACACCGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W3K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W3I1

References