Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2758500..2759026 Replicon chromosome
Accession NZ_CP015137
Organism Dickeya solani IPO 2222

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag A4U42_RS11860 Protein ID WP_022632051.1
Coordinates 2758500..2758805 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag A4U42_RS11865 Protein ID WP_022632052.1
Coordinates 2758808..2759026 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U42_RS11840 2753716..2754113 + 398 Protein_2323 DUF3577 domain-containing protein -
A4U42_RS11845 2754229..2755500 + 1272 WP_022632048.1 hypothetical protein -
A4U42_RS11850 2755504..2756082 + 579 WP_023637591.1 hypothetical protein -
A4U42_RS11855 2756070..2758010 + 1941 WP_022632050.1 hypothetical protein -
A4U42_RS11860 2758500..2758805 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
A4U42_RS11865 2758808..2759026 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
A4U42_RS11870 2759085..2759828 - 744 WP_022632053.1 hypothetical protein -
A4U42_RS11875 2760731..2761081 - 351 WP_013316250.1 hypothetical protein -
A4U42_RS22120 2761204..2761392 + 189 WP_033111580.1 hypothetical protein -
A4U42_RS11880 2761532..2762791 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
A4U42_RS11890 2763189..2763764 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2752637..2762968 10331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T62453 WP_022632051.1 NZ_CP015137:c2758805-2758500 [Dickeya solani IPO 2222]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T62453 NZ_CP015137:c2758805-2758500 [Dickeya solani IPO 2222]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATCGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCGCTTATCGAAGCACACCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTAAGA
TCCGCATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTACCTGTTGAAGTCATGGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT62453 WP_022632052.1 NZ_CP015137:c2759026-2758808 [Dickeya solani IPO 2222]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT62453 NZ_CP015137:c2759026-2758808 [Dickeya solani IPO 2222]
ATGAAACACCGCGTCAGTGTTACCGTAGACAAAGACAACTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGGAGTGGAAGAAAGAAAACAGTGAGGGGATGGAGG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References