Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2154133..2155721 Replicon chromosome
Accession NZ_CP015137
Organism Dickeya solani IPO 2222

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8W078
Locus tag A4U42_RS09090 Protein ID WP_022635525.1
Coordinates 2154402..2155721 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8W0B1
Locus tag A4U42_RS09085 Protein ID WP_022635524.1
Coordinates 2154133..2154402 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U42_RS09060 2149451..2150062 - 612 WP_022635519.1 NAD(P)-dependent oxidoreductase -
A4U42_RS09065 2150204..2150590 + 387 WP_022635520.1 helix-turn-helix transcriptional regulator -
A4U42_RS09070 2150689..2151774 - 1086 WP_022635521.1 4-hydroxyphenylpyruvate dioxygenase -
A4U42_RS09075 2152089..2152862 + 774 WP_022635522.1 MBL fold metallo-hydrolase -
A4U42_RS09080 2152906..2153862 + 957 WP_026595316.1 helix-turn-helix domain-containing protein -
A4U42_RS09085 2154133..2154402 + 270 WP_022635524.1 helix-turn-helix domain-containing protein Antitoxin
A4U42_RS09090 2154402..2155721 + 1320 WP_022635525.1 type II toxin-antitoxin system HipA family toxin Toxin
A4U42_RS09095 2155793..2157157 - 1365 WP_022635526.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
A4U42_RS09100 2157273..2158904 - 1632 WP_022635527.1 membrane protein insertase YidC -
A4U42_RS21260 2158907..2159164 - 258 WP_071598660.1 membrane protein insertion efficiency factor YidD -
A4U42_RS09105 2159128..2159487 - 360 WP_022635528.1 ribonuclease P protein component -
A4U42_RS21265 2159506..2159646 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49161.32 Da        Isoelectric Point: 6.6616

>T62451 WP_022635525.1 NZ_CP015137:2154402-2155721 [Dickeya solani IPO 2222]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE

Download         Length: 1320 bp

>T62451 NZ_CP015137:2154402-2155721 [Dickeya solani IPO 2222]
ATGGCGGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGAATTCTGACCAAAACGGGCAGTGGCGCGCATCATTTTTC
CTATGATGCGAACTGGCTCGAGTTGCCGGGGAGTCGCCCCCTCTCGCTCTCAATGCCGCTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAACTTGTTGCCGGATAACCCGGATATCAGGCGGCGGATTGTCACCAGGCATCAG
GCGGATTCCACCCAGCCGTTTGATTTGCTGGCTAAAGTGGGGCAAGACAGTGTTGGGGCGTTGCAATTGGTGCCGCAGGG
CACCGCTGTTGGCGATATAAAACAGATCGAATACAAAACCTTATCCGAGCAACAGCTTGAAAACATACTGGCGGGATATC
TGTCCGATGCCCCGCTCGGGATGATTGATACAGAAGAGGATTTTCGTATCTCTATCGCAGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGGCAGCTGGTGTTTGCCTCTTAATACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATTGAGAGTCATTCATACTCAATTGATATGTCTGACAGCGTTGAAAATGAATACCTGTGCCTGCTCATTGCCAAGGCGT
TTGGGCTGTCGGTACCGCACTGTTTTATGATCACAGCAGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGTAAA
TACGCCTCGGATGGTCGTTGGATTATGCGGTTGCCGCAGGAGGATTTTTGCCAGGTATTAAACGTGCCTTCCGCACGAAA
ATACGAAAATCATGGTGGACCGGGCATTTCCGCTATTATGTCGGTGCTATTAGGGGCGATTGAACCTGAAAGGGATCGCT
ATACCTTTATGAAGGCGCAGGTGCTGTTTTGGCTATTGGCTGCAACGGATGGACATGCAAAAAACTTCTCCCTGTTTATT
GAATTTGAAGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGCGGGCGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGGCTGACCGGCTCAAAAGGCAAGAAATACGCCATTGAGCAGATCTTTCCACGGC
ACTTTTTCCAAACGGCAAAGGTGGTTGGATTTGCCAGAGAATCGATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATCCGCGATGCGATCCTGGGAGGGCT
ACAGACTAGATCGAGTCGATTGACGACGGGCTGGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.26 Da        Isoelectric Point: 10.0983

>AT62451 WP_022635524.1 NZ_CP015137:2154133-2154402 [Dickeya solani IPO 2222]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Download         Length: 270 bp

>AT62451 NZ_CP015137:2154133-2154402 [Dickeya solani IPO 2222]
ATGAAGGTCACCAACAGCAAACAGCTTAGCAGCTATCTAAAAGATGTTCGTATCACGCAGAAGCTTTCCCAAGGGAAAGT
GGCCAGTAAAGTGGGGATTCGTCAGGACACGGTATCGAGCTTCGAACAACATCCCGATTCCACCAAGCTGGAAACCTTCT
TTAAGATCCTGTCGGCATTAAATTTAGAACTTACCATTACCCCCAGAAATGCGCATGCAGCCAATAACGAGGCTTCTGTT
GCAACATCAGCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W078

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W0B1

References