Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1005200..1007040 Replicon chromosome
Accession NZ_CP015137
Organism Dickeya solani IPO 2222

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8VX87
Locus tag A4U42_RS04260 Protein ID WP_022634631.1
Coordinates 1005694..1007040 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A4U42_RS04255 Protein ID WP_099048985.1
Coordinates 1005200..1005583 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U42_RS04230 1000517..1001356 - 840 WP_022634625.1 MurR/RpiR family transcriptional regulator -
A4U42_RS04235 1001531..1003120 + 1590 WP_022634626.1 gamma-glutamyltransferase family protein -
A4U42_RS04240 1003165..1003362 + 198 WP_022634627.1 oxalurate catabolism protein HpxX -
A4U42_RS04245 1003359..1004771 + 1413 WP_022634628.1 AtzE family amidohydrolase -
A4U42_RS04250 1004768..1005148 + 381 WP_022634629.1 oxalurate catabolism protein HpxZ -
A4U42_RS04255 1005200..1005583 - 384 WP_099048985.1 helix-turn-helix domain-containing protein Antitoxin
A4U42_RS04260 1005694..1007040 - 1347 WP_022634631.1 type II toxin-antitoxin system HipA family toxin Toxin
A4U42_RS04265 1007313..1008260 - 948 WP_022634632.1 allantoinase PuuE -
A4U42_RS04270 1008304..1009041 - 738 WP_022634633.1 allantoin racemase -
A4U42_RS04275 1009038..1009781 - 744 WP_022634634.1 GntR family transcriptional regulator -
A4U42_RS04280 1009934..1011418 + 1485 WP_022634635.1 NCS1 family nucleobase:cation symporter-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-104)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50541.28 Da        Isoelectric Point: 4.9663

>T62450 WP_022634631.1 NZ_CP015137:c1007040-1005694 [Dickeya solani IPO 2222]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

>T62450 NZ_CP015137:c1007040-1005694 [Dickeya solani IPO 2222]
ATGGAACGACTGACTGTACAGGCGTTTATCGATAATGCGTGGCAGGATATTGCCGAGATCGGTTTTCCCGAGAGCGACCA
GGATAATTACCTGCTGACCCGGCTGGATTATGCGTCCGATTATGGCCTTGACTATATGGATTGCGACGACCACCACGCGG
TTTCCGTCAATTACCCGGTTCGGATCTTCTTTGATGATGGCGGTGAGCTCGGATGGATGCGCTTTCTGGATGACATCATG
CCGGCGGGGGCCAGCCGAAAATATTGGGTTGACCACCTTGATCTCTCGGGGCTGCCGGCACCGTTGCAAAATTATGTCTT
GCTGCGGCATGCCACCATCGCACCGGTCGGTAATTTGCGCATCAAGGAGTCGATTCCTGTGCGGCATGAAGGTGCAACCC
GCTTTTTCAGCGTGGAGGATGTGAAGAACCGGGCTGCCGATTTTCTGGATTATGCGCAGCAGCGCGGTGCCGCTGCCGGG
GGCGCTACAGGGGCGGGCGGTGAGGCGCCAAAGCTGCTGTTGCGTTGTAATGCCGACGATCGGGTGTGGATCGATACCTG
GCAGGATAAGACCGACTGCCGCGATACCGCCTATCTGGTGAAGTTTCCGCGCGGGCAACGCAGTGAGATTGACTGCGACA
TCCTGCGGGCCGAGTTTCATTACTACCATGAATTAGCCGCGATGGGGTTCGACACCATTCCTGTGGCGGGCATGCGTCTG
GAAGAGGGGCGGCATTACCCGTCGCTCTGGTTGCCGCGTTTTGATATCGAATTCCCCGGCGATGGGCGCGTGAAGCGTTA
TGGCATGGAATCAGTTTATTCCCTGTTGCGGGCCGGGCCGGGCAGCGCGCTGCGGCACGATCAAACGATTCGGGCGGTGA
TCGCCAAAATAGCGTCCAGCCATACGGTCAGCGTCGAGGGAAAGCCATTCGACCAAGCGGCGTTCGTGATCGAGTGGGTG
CGCCGCGATGTGCTGAATATTGCCTTCGGCAACAGCGATAACCACGGCCGCAATACCGCGTTTCTCAAGGACGAACAGGG
GATTCGGCTGGCGCCGATTTACGACTTCGCGCCGATGAAGGCCGACCCGGCAGGCATTGCCAGAGCGACCAAATGGCCGG
AGCCGCTGGAAATCGGCGGTGATTATCAGTTTGAGTGGATCGCGGAGCAGTTGTCCGACATGCTCCCGCCGGCGCTGTTG
ATGGAGAGATTGCGCGAGACGGCGGTGCAACTGGTTGGACTGAAAGCGCGGCTTCAGGCGCGCGGTGTGCCCGAGTCGAT
CCTAACCATGCCTTCCATCGGGTTTGATTACCTTCCTGAAAAGCTACAGCGGTGGGGGTTGTTATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13731.06 Da        Isoelectric Point: 10.8242

>AT62450 WP_099048985.1 NZ_CP015137:c1005583-1005200 [Dickeya solani IPO 2222]
MLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRRMMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTL
SEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATAPASR

Download         Length: 384 bp

>AT62450 NZ_CP015137:c1005583-1005200 [Dickeya solani IPO 2222]
ATGCTGCGTCCCCCGGTCATTGCCGTGGCGGAGACGGCGGATATTCCCAAAGCGAGAGCATCAAAAAATTCCAGACCACT
CAATGCCAGTGAGAGACAGTCTGCGATGCAAAGCATTATCCGCAGGATGATGGTCGGGGAGATATCGCAGGGAAACGCGC
TCAGGGAATTGCGTCTCAGCGTTCTGGGGCTCAAGCAGGATGCCTACGCCAGTCTGGTAGGCGTGTCGCGCAAGACCTTG
TCCGAAATCGAGAATGACAAAGGCAATTACACGGCGGATATCATCAACAAGGTCTTTAAACCCTTTGGTCTGAAGATGGG
ATTAATTCCGGTATCGCCTTCTTTGCTCGCCGAGATACTCGCCACCGCGCCAGCCTCTCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8VX87

Antitoxin

Source ID Structure

References