Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 6733994..6734580 Replicon chromosome
Accession NZ_CP015136
Organism Luteitalea pratensis strain DSM 100886 isolate HEG_-6_39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LuPra_RS28240 Protein ID WP_110173867.1
Coordinates 6734212..6734580 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LuPra_RS28235 Protein ID WP_110173866.1
Coordinates 6733994..6734212 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LuPra_RS28210 6729240..6730148 + 909 WP_110173861.1 VWA domain-containing protein -
LuPra_RS28215 6730353..6731456 + 1104 WP_110173862.1 TIM barrel protein -
LuPra_RS28220 6731453..6732967 + 1515 WP_110173863.1 sulfatase -
LuPra_RS28225 6732969..6733277 - 309 WP_157899791.1 hypothetical protein -
LuPra_RS28230 6733274..6733969 - 696 WP_110173865.1 hypothetical protein -
LuPra_RS28235 6733994..6734212 + 219 WP_110173866.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LuPra_RS28240 6734212..6734580 + 369 WP_110173867.1 PIN domain-containing protein Toxin
LuPra_RS28245 6734806..6735672 + 867 WP_110173868.1 NAD(P)-dependent oxidoreductase -
LuPra_RS28250 6735822..6736952 + 1131 WP_110173869.1 lytic murein transglycosylase -
LuPra_RS28255 6737011..6737502 - 492 WP_110173870.1 peroxiredoxin -
LuPra_RS28260 6737687..6738631 - 945 WP_110174906.1 homocysteine S-methyltransferase family protein -
LuPra_RS28265 6738805..6739422 - 618 WP_110173871.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-115)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13757.92 Da        Isoelectric Point: 6.9791

>T62448 WP_110173867.1 NZ_CP015136:6734212-6734580 [Luteitalea pratensis]
MVLVDTSVWIRFLANRAPFARQLDELLGQGEVCGHDFVMGELLIGDKGGRKQLLADYALMRQAPVVSHREVVEFVRQRRL
HGRGIGWIDTHLLASALVSHIKLWTADPRLGEVARDLGIDYE

Download         Length: 369 bp

>T62448 NZ_CP015136:6734212-6734580 [Luteitalea pratensis]
ATGGTTCTTGTCGATACGTCGGTCTGGATACGCTTTCTTGCCAACCGGGCACCGTTTGCCCGGCAGCTCGATGAGCTGCT
CGGTCAGGGCGAGGTCTGCGGCCATGACTTCGTGATGGGTGAACTCCTGATTGGCGACAAGGGCGGCCGTAAGCAGCTCC
TGGCCGACTACGCGCTCATGCGCCAGGCGCCTGTCGTGTCGCACCGCGAGGTGGTCGAGTTCGTTCGCCAGCGCAGACTT
CACGGCCGTGGCATCGGATGGATCGACACGCACCTCCTCGCGTCGGCACTCGTGTCGCACATCAAGTTGTGGACCGCCGA
CCCTCGGCTCGGAGAGGTCGCGCGCGACCTGGGGATCGATTACGAATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8078.13 Da        Isoelectric Point: 11.6228

>AT62448 WP_110173866.1 NZ_CP015136:6733994-6734212 [Luteitalea pratensis]
MKKTLHIDDDLLREARSVSGARSDTDTVRLGLEALVRQGANERLRALRGKEPRATDVRRRREVSSPTKHSAA

Download         Length: 219 bp

>AT62448 NZ_CP015136:6733994-6734212 [Luteitalea pratensis]
ATGAAGAAGACACTTCACATCGACGACGACCTCTTGCGAGAGGCGCGATCGGTCAGTGGCGCCCGGAGTGACACGGATAC
GGTCCGCCTCGGGCTCGAGGCGCTGGTGCGGCAAGGCGCGAATGAGCGACTGCGGGCACTTCGGGGGAAGGAGCCGCGGG
CTACTGATGTTCGGCGTCGACGTGAAGTCTCCTCGCCAACGAAACACTCTGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References