Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 5187582..5188201 Replicon chromosome
Accession NZ_CP015136
Organism Luteitalea pratensis strain DSM 100886 isolate HEG_-6_39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LuPra_RS21735 Protein ID WP_201792163.1
Coordinates 5187809..5188201 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LuPra_RS21730 Protein ID WP_169812026.1
Coordinates 5187582..5187812 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LuPra_RS21715 5183207..5185828 - 2622 WP_110172691.1 PD40 domain-containing protein -
LuPra_RS21720 5185991..5186689 - 699 WP_157899521.1 hypothetical protein -
LuPra_RS21725 5186799..5187476 + 678 WP_110172693.1 winged helix-turn-helix domain-containing protein -
LuPra_RS21730 5187582..5187812 + 231 WP_169812026.1 hypothetical protein Antitoxin
LuPra_RS21735 5187809..5188201 + 393 WP_201792163.1 type II toxin-antitoxin system VapC family toxin Toxin
LuPra_RS21740 5188403..5188666 - 264 WP_162271256.1 hypothetical protein -
LuPra_RS21745 5188612..5188854 - 243 WP_157899522.1 PD40 domain-containing protein -
LuPra_RS21750 5188923..5189015 + 93 Protein_4268 carboxylesterase family protein -
LuPra_RS21765 5190187..5190504 - 318 WP_110172698.1 multidrug efflux SMR transporter -
LuPra_RS21770 5190688..5191092 - 405 WP_110174814.1 YraN family protein -
LuPra_RS21775 5191278..5192075 - 798 WP_110174815.1 sugar phosphate isomerase/epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14384.60 Da        Isoelectric Point: 5.2047

>T62447 WP_201792163.1 NZ_CP015136:5187809-5188201 [Luteitalea pratensis]
VIVVDASAMLEFLLQTALGTRVEARLFRDRDELHAPHLVDVEVLQALRRLVRLGEVSPSRADEVIADLSDLDLHRHAHLD
LLARAWKLRDNVSAYDAVYVALAEAMEAAIVTCDGPLAKAGNRIRIELIA

Download         Length: 393 bp

>T62447 NZ_CP015136:5187809-5188201 [Luteitalea pratensis]
GTGATCGTCGTCGATGCGTCGGCGATGCTGGAGTTCCTCCTCCAAACTGCGCTTGGCACTCGGGTCGAGGCGCGCCTCTT
TCGCGACCGGGACGAGCTTCATGCGCCGCACCTGGTCGACGTGGAGGTGCTTCAAGCCCTGCGACGCCTCGTGCGATTGG
GCGAAGTCTCTCCCAGCCGCGCCGACGAGGTGATTGCCGATCTCAGCGACCTCGATCTCCACCGCCACGCGCATCTCGAT
CTCCTGGCGCGCGCGTGGAAGCTACGAGACAACGTGAGTGCATACGACGCCGTATACGTCGCTCTTGCAGAGGCGATGGA
GGCGGCGATCGTCACCTGCGACGGACCGCTCGCCAAGGCTGGTAACCGTATTCGGATCGAGTTGATCGCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8681.03 Da        Isoelectric Point: 11.5967

>AT62447 WP_169812026.1 NZ_CP015136:5187582-5187812 [Luteitalea pratensis]
MSRMVQVRNVPDALHRKLKARAADAGQTLSDYLLAELERLATRPTRDEMLARLHSRRRVTLKTPAATVIRDERESA

Download         Length: 231 bp

>AT62447 NZ_CP015136:5187582-5187812 [Luteitalea pratensis]
ATGTCACGAATGGTCCAGGTTCGCAACGTGCCGGACGCGCTGCACCGTAAGCTGAAAGCCCGAGCGGCCGATGCCGGACA
GACGCTGTCCGACTATCTGCTGGCCGAGTTGGAGCGGCTGGCCACACGTCCCACACGTGACGAGATGCTGGCCAGGCTCC
ACAGTCGTAGGCGTGTGACGTTGAAGACGCCAGCCGCCACCGTCATCCGCGACGAGCGCGAATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References