Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1770443..1770959 Replicon chromosome
Accession NZ_CP015134
Organism Klebsiella pneumoniae strain ATCC 35657

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag WM93_RS09255 Protein ID WP_004178374.1
Coordinates 1770675..1770959 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag WM93_RS09250 Protein ID WP_002886901.1
Coordinates 1770443..1770685 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM93_RS09235 1766471..1767211 + 741 WP_002886899.1 KDGP aldolase family protein -
WM93_RS09240 1767278..1768432 + 1155 WP_002886900.1 lactonase family protein -
WM93_RS09245 1768455..1770365 + 1911 WP_075394523.1 BglG family transcription antiterminator -
WM93_RS09250 1770443..1770685 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WM93_RS09255 1770675..1770959 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM93_RS09260 1770963..1771427 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WM93_RS09265 1771735..1773873 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
WM93_RS09275 1774230..1774973 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
WM93_RS28855 1774976..1775149 - 174 WP_075394524.1 hypothetical protein -
WM93_RS09285 1775234..1775542 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T62430 WP_004178374.1 NZ_CP015134:1770675-1770959 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T62430 NZ_CP015134:1770675-1770959 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT62430 WP_002886901.1 NZ_CP015134:1770443-1770685 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT62430 NZ_CP015134:1770443-1770685 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References