Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3801237..3801753 Replicon chromosome
Accession NZ_CP015130
Organism Klebsiella pneumoniae strain Kpn555

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag WM92_RS19010 Protein ID WP_002886902.1
Coordinates 3801469..3801753 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag WM92_RS19005 Protein ID WP_002886901.1
Coordinates 3801237..3801479 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM92_RS18990 3797265..3798005 + 741 WP_002886899.1 KDGP aldolase family protein -
WM92_RS18995 3798072..3799226 + 1155 WP_064839881.1 lactonase family protein -
WM92_RS19000 3799249..3801159 + 1911 WP_064839883.1 BglG family transcription antiterminator -
WM92_RS19005 3801237..3801479 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WM92_RS19010 3801469..3801753 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM92_RS19015 3801757..3802221 - 465 WP_064839885.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WM92_RS19020 3802462..3804600 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
WM92_RS19030 3804957..3805700 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
WM92_RS31680 3805703..3805876 - 174 WP_064839887.1 hypothetical protein -
WM92_RS19040 3805961..3806269 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T62420 WP_002886902.1 NZ_CP015130:3801469-3801753 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T62420 NZ_CP015130:3801469-3801753 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT62420 WP_002886901.1 NZ_CP015130:3801237-3801479 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT62420 NZ_CP015130:3801237-3801479 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References