Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2383138..2383795 Replicon chromosome
Accession NZ_CP015130
Organism Klebsiella pneumoniae strain Kpn555

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag WM92_RS11850 Protein ID WP_002916310.1
Coordinates 2383138..2383548 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag WM92_RS11855 Protein ID WP_002916312.1
Coordinates 2383529..2383795 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM92_RS11830 2379138..2380871 - 1734 WP_019704911.1 single-stranded-DNA-specific exonuclease RecJ -
WM92_RS11835 2380877..2381590 - 714 WP_023342185.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
WM92_RS11840 2381613..2382509 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
WM92_RS11845 2382610..2383131 + 522 WP_004144730.1 flavodoxin FldB -
WM92_RS11850 2383138..2383548 - 411 WP_002916310.1 protein YgfX Toxin
WM92_RS11855 2383529..2383795 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
WM92_RS11860 2384041..2385024 + 984 WP_064839573.1 tRNA-modifying protein YgfZ -
WM92_RS11865 2385123..2385782 - 660 WP_002916317.1 hemolysin III family protein -
WM92_RS11870 2385946..2386257 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
WM92_RS11875 2386307..2387035 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
WM92_RS11880 2387154..2388587 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T62415 WP_002916310.1 NZ_CP015130:c2383548-2383138 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T62415 NZ_CP015130:c2383548-2383138 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT62415 WP_002916312.1 NZ_CP015130:c2383795-2383529 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT62415 NZ_CP015130:c2383795-2383529 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References