Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 454043..454696 Replicon chromosome
Accession NZ_CP015121
Organism Acinetobacter baumannii strain ab736

Toxin (Protein)


Gene name cptA Uniprot ID D0CD27
Locus tag A4U85_RS02175 Protein ID WP_000607073.1
Coordinates 454307..454696 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag A4U85_RS02170 Protein ID WP_001288210.1
Coordinates 454043..454300 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U85_RS02150 449558..450565 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
A4U85_RS02155 450584..450961 + 378 WP_001216380.1 50S ribosomal protein L17 -
A4U85_RS02160 451143..452633 + 1491 WP_000415127.1 NAD(P)/FAD-dependent oxidoreductase -
A4U85_RS02165 452683..453855 - 1173 WP_001190553.1 acyl-CoA dehydrogenase family protein -
A4U85_RS02170 454043..454300 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
A4U85_RS02175 454307..454696 + 390 WP_000607073.1 membrane protein Toxin
A4U85_RS02180 455466..456548 + 1083 WP_000049103.1 hypothetical protein -
A4U85_RS02185 456627..457193 + 567 WP_000651536.1 rhombosortase -
A4U85_RS02190 457381..459576 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T62404 WP_000607073.1 NZ_CP015121:454307-454696 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T62404 NZ_CP015121:454307-454696 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT62404 WP_001288210.1 NZ_CP015121:454043-454300 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT62404 NZ_CP015121:454043-454300 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0CD27

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References